Department of Rehabilitation, Matsumoto City Hospital, Nagano, Japan.
Department of Rehabilitation, Matsumoto City Hospital, 4417-180 Hata, Matsumoto, Nagano, 390-1401, Japan.
Sci Rep. 2020 Oct 23;10(1):18195. doi: 10.1038/s41598-020-75405-x.
Patients with non-dialysis chronic kidney disease (CKD) are at greater risk of early mortality and decreased physical function with an advance in the stage of CKD. However, the effect of exercise in these patients is unclear. This meta-analysis aimed to determine the effects of physical exercise training on the risk of mortality, kidney and physical functions, and adverse events in patients with non-dialysis CKD. The meta-analysis conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement and the Cochrane Handbook recommendations. On 16 August 2019, the PubMed, CINAHL, Cochrane Library databases, and Embase were electronically searched, with no restrictions for date/time, language, document type, or publication status, for eligible randomized controlled trials (RCTs) investigating the effects of exercise on mortality and kidney and physical function in patients with non-dialysis CKD. Eighteen trials (28 records), including 848 patients, were analyzed. The effects of exercise on all-cause mortality and estimated glomerular filtration rate were not significantly different from that of usual care. Exercise training improved peak/maximum oxygen consumption compared to usual care. Regular exercise improves physical and walking capacity for patients with non-dialysis CKD. Effect on leg muscle strength was unclear.
患有非透析慢性肾脏病（CKD）的患者随着 CKD 阶段的进展，其早期死亡率和身体功能下降的风险更高。然而，运动对这些患者的影响尚不清楚。本荟萃分析旨在确定身体运动训练对非透析 CKD 患者的死亡率、肾脏和身体功能以及不良事件风险的影响。该荟萃分析符合系统评价和荟萃分析的首选报告项目（PRISMA）声明和 Cochrane 手册建议。于 2019 年 8 月 16 日，电子检索了 PubMed、CINAHL、Cochrane 图书馆数据库和 Embase，对纳入的随机对照试验（RCT）没有时间/日期、语言、文件类型或出版状态的限制，这些 RCT 研究了运动对非透析 CKD 患者死亡率和肾脏及身体功能的影响。共分析了 18 项试验（28 条记录），包括 848 名患者。运动对全因死亡率和估计肾小球滤过率的影响与常规护理没有显著差异。与常规护理相比，运动训练可提高峰值/最大耗氧量。定期运动可改善非透析 CKD 患者的身体和步行能力。对腿部肌肉力量的影响尚不清楚。
