Institute of Enzymology, Research Centre of Natural Sciences, Eötvös Loránd Research Network, Budapest, Hungary.
Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.
FEBS Lett. 2020 Dec;594(23):3965-3985. doi: 10.1002/1873-3468.13967. Epub 2020 Nov 28.
ABC transporters fulfill diverse physiological functions in different cellular localizations ranging from the plasma membrane to intracellular membranous compartments. Several ABC transporters have been spotted in the endolysosomal system, which consists of endosomes, autophagosomes, lysosomes, and lysosome-related organelles. In this review, we present an overview of lysosomal ABC transporters including ABCA2, ABCA3, ABCA5, ABCB6, ABCB9, and ABCD4, discussing their trafficking routes, putative substrates, potential physiological functions, and associated diseases. In addition, we offer a critical evaluation of the literature linking ABC transporters to lysosomal drug sequestration, examining pitfalls associated with in vitro models of drug resistance.
ABC 转运蛋白在不同的细胞定位中发挥着多样化的生理功能，从质膜到细胞内膜隔室。几种 ABC 转运蛋白已在包含内体、自噬体、溶酶体和溶酶体相关细胞器的内溶酶体系统中被发现。在这篇综述中，我们介绍了溶酶体 ABC 转运蛋白，包括 ABCA2、ABCA3、ABCA5、ABCB6、ABCB9 和 ABCD4，讨论了它们的运输途径、可能的底物、潜在的生理功能和相关疾病。此外，我们还对将 ABC 转运蛋白与溶酶体药物隔离联系起来的文献进行了批判性评估，研究了与耐药性的体外模型相关的缺陷。
