用于治疗儿童斑秃的JAK抑制剂
JAK Inhibitors for the Treatment of Pediatric Alopecia Areata.
作者信息
Hamilton Claire E, Craiglow Brittany G
机构信息
Department of Dermatology, Yale University, New Haven, Connecticut, USA.
Department of Dermatology, Yale University, New Haven, Connecticut, USA; Dermatology Physicians of Connecticut, Fairfield, Connecticut, USA.
出版信息
J Investig Dermatol Symp Proc. 2020 Nov;20(1):S31-S36. doi: 10.1016/j.jisp.2020.04.005.
Alopecia areata is a common autoimmune condition that disproportionately affects children and can significantly hinder quality of life. Few safe and effective therapies are available for the treatment of severely affected pediatric patients. JAK inhibitors have been recently established as an effective and well-tolerated therapy in adults, but there are limited data regarding the use of JAK inhibitors to treat alopecia areata in children. Here, we review the available literature regarding the use of JAK inhibitors in children in dermatology and across other medical disciplines.
斑秃是一种常见的自身免疫性疾病，对儿童的影响尤为严重，会显著影响生活质量。对于严重患病的儿科患者，几乎没有安全有效的治疗方法。JAK抑制剂最近已被确立为成人斑秃的一种有效且耐受性良好的治疗方法，但关于使用JAK抑制剂治疗儿童斑秃的数据有限。在此，我们综述了皮肤科及其他医学学科中关于儿童使用JAK抑制剂的现有文献。
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