Tomczyk-Warunek Agnieszka, Dubiel Anna, Poleszak Ewa, Blicharski Rudolf, Dobrzyński Maciej
CHAIR AND DEPARTMENT OF REHABILITATION AND ORTHOPAEDICS, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
DEPARTMENT OF APPLIED AND SOCIAL PHARMACY, LABORATORY OF PRECLINICAL TESTING, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.
Wiad Lek. 2020;73(9 cz. 1):1835-1839.
The intestinal microflora plays an important role in the proper functioning of human. It is complex, diverse and dynamic ecosystem that constantly strives to maintain homeostasis throughout the body. The process of acquiring intestinal microflora begins immediately after human birth. Elementary factors that determine the modification of the composition of the microflora are age, sex, diet, lifestyle. Determinate individual composition of the microflora. Microorganisms inhabiting the intestine perform various functions, from metabolic, immune to trophic. Early changes in the intestinal microflora are reflected in the state of human health. Recently, many studies have been carried out confirming the hypothesis that the bacterial flora of the gastrointestinal tract affects the normal metabolism of bone tissue, and disorders in its composition can lead to the appearance of bumps in the processes of physiological remodeling of bone tissue and contribute to the formation of many inflammations. Microorganisms that rot in the digestive tract regulate bone metabolism through three mechanisms: the impact on the immune system, the hormonal system and the impact on the absorption of minerals. Disorders in the microflora of the digestive tract can lead to the development of inflammatory bowel diseases, and as a consequence to the accelerated development of osteoporosis or arthrosis of the joints. The aim: To collect available publications confirming the impact of microflora on the skeletal system.
肠道微生物群在人体正常功能中发挥着重要作用。它是一个复杂、多样且动态的生态系统，不断努力维持全身的稳态。获取肠道微生物群的过程在人类出生后立即开始。决定微生物群组成变化的基本因素包括年龄、性别、饮食和生活方式。这些因素决定了微生物群的个体组成。栖息在肠道中的微生物执行各种功能，从代谢、免疫到营养方面。肠道微生物群的早期变化反映在人类健康状况上。最近，许多研究证实了胃肠道细菌菌群影响骨组织正常代谢这一假设，其组成紊乱会导致骨组织生理重塑过程中出现异常，并促使多种炎症的形成。在消化道中繁衍的微生物通过三种机制调节骨代谢：对免疫系统的影响、对激素系统的影响以及对矿物质吸收的影响。消化道微生物群紊乱可导致炎症性肠病的发展，进而导致骨质疏松或关节性关节炎加速发展。目的：收集现有出版物，证实微生物群对骨骼系统的影响。
