Alaska SeaLife Center, College of Fisheries and Ocean Sciences, Seward, AK 99664, USA,
Alaska SeaLife Center, College of Fisheries and Ocean Sciences, Seward, AK 99664, USA.
J Avian Med Surg. 2020 Oct 20;34(3):302-305. doi: 10.1647/1082-6742-34.3.302.
This report details 2 different presentations of lymphoma in captive Steller's eiders (). A female Steller's eider, at least 10 years old, developed lameness and lethargy. A complete blood cell count (CBC) revealed a severely elevated total white blood cell (WBC) count with a lymphocytosis. A subsequent liver biopsy confirmed a diagnosis of lymphoma and lymphocytic leukemia. The female Steller's eider was euthanatized 11 days after presentation. On necropsy, neoplastic lymphoid infiltrates were present in multiple tissues, primarily in the skin and subcutis. The results of a CBC from an apparently healthy male Steller's eider, at least 14 years old, also indicated this bird had an increased WBC count with a lymphocytosis. Serum submitted for protein electrophoresis indicated that this bird had a monoclonal gammopathy. Lymphocytes isolated from the male Steller's eider had low levels of proliferation in response to mitogens. The bird survived nearly 2 years without treatment, and the WBC count continued to increase during this time. The male Steller's eider maintained good body condition and exhibited normal behavior throughout the course of the disease until a sudden decline just prior to death. Lymphoma was diagnosed based on histopathology results. Infiltrates of atypical lymphocytes were observed in the bone marrow, proventriculus, ventriculus, heart, and eyes.
本报告详细介绍了 2 例圈养斑海豹（）淋巴瘤的不同表现。一只至少 10 岁的雌性斑海豹出现跛行和嗜睡。全血细胞计数（CBC）显示总白细胞（WBC）严重升高，伴有淋巴细胞增多。随后的肝活检证实了淋巴瘤和淋巴细胞白血病的诊断。这只雌性斑海豹在出现症状后 11 天被安乐死。尸检时，在多个组织中发现了肿瘤性淋巴样浸润，主要在皮肤和皮下组织。一只至少 14 岁的健康雄性斑海豹的 CBC 结果也表明这只鸟的白细胞计数增加，伴有淋巴细胞增多。提交的血清蛋白电泳表明这只鸟患有单克隆丙种球蛋白病。从雄性斑海豹分离的淋巴细胞对有丝分裂原的增殖反应水平较低。这只鸟在没有治疗的情况下存活了近 2 年，在此期间白细胞计数继续增加。这只雄性斑海豹在整个疾病过程中保持良好的身体状况和正常的行为，直到死亡前突然下降。根据组织病理学结果诊断为淋巴瘤。在骨髓、前胃、胃、心脏和眼睛中观察到异常淋巴细胞浸润。
