Naik Shailendra S, Vanidassane Ilavarasi, Dhamija Ekta, Sharma Atul
Department of Radiodiagnosis, IRCH, AIIMS, New Delhi, India.
Department of Medical Oncology, IRCH, AIIMS, New Delhi, India.
Indian J Radiol Imaging. 2020 Apr-Jun;30(2):214-217. doi: 10.4103/ijri.IJRI_17_19. Epub 2020 Jul 13.
5-Fluorouracil (5-FU), a commonly used antimetabolite and antineoplastic agent, has been approved for the treatment of various cancers. It is associated with systemic side-effects such as gastrointestinal problems, neutropenia. 5-FU-related encephalopathy is very rarely reported. Imaging with computed tomography (CT) and magnetic resonance imaging (MRI) plays a key role in diagnosing and monitoring the changes. Since the prognosis of cerebral involvement is usually good if recognized and treated in time, the reporting radiologist and treating physician should be familiar with them. We present a rare case of 5-FU-induced encephalopathy that was diagnosed based on her clinical and MRI findings and managed successfully.
5-氟尿嘧啶（5-FU）是一种常用的抗代谢和抗肿瘤药物，已被批准用于治疗各种癌症。它会引发全身性副作用，如胃肠道问题、中性粒细胞减少。5-氟尿嘧啶相关的脑病报道非常罕见。计算机断层扫描（CT）和磁共振成像（MRI）在诊断和监测病情变化中起着关键作用。由于脑部受累如果及时识别和治疗，预后通常良好，报告的放射科医生和治疗医生应熟悉这些情况。我们报告一例罕见的5-氟尿嘧啶诱发的脑病，该病例根据临床和MRI表现得以诊断，并成功治愈。
