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组织蛋白酶F是一种最近进化而来的半胱氨酸蛋白酶。

Cathepsin F of is a recently evolved cysteine protease.

作者信息

Sloan Sarah, Jenvey Caitlin, Cairns Callum, Stear Michael

机构信息

AgriBio Centre for AgriBioscience, Department of Animal, Plant and Soil Sciences, School of Life Sciences, La Trobe University, Bundoora, Victoria, Australia.

出版信息

Evol Bioinform Online. 2020 Oct 10;16:1176934320962521. doi: 10.1177/1176934320962521. eCollection 2020.

DOI:10.1177/1176934320962521
PMID:33100828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7549167/
Abstract

Parasitic cysteine proteases are involved in parasite stage transition, invasion of host tissues, nutrient uptake, and immune evasion. The cysteine protease cathepsin F is the most abundant protein produced by fourth-stage larvae (L4) of the nematode , while its transcript is only detectable in L4 and adults. cathepsin F is a recently evolved cysteine protease that does not fall clearly into either of the cathepsin L or F subfamilies. This protein exhibits characteristics of both cathepsins F and L, and its phylogenetic relationship to its closest homologs is distant, including proteins of closely related nematodes of the same subfamily.

摘要

寄生性半胱氨酸蛋白酶参与寄生虫的阶段转变、宿主组织侵袭、营养摄取和免疫逃避。半胱氨酸蛋白酶组织蛋白酶F是线虫第四期幼虫（L4）产生的最丰富的蛋白质，而其转录本仅在L4期幼虫和成虫中可检测到。组织蛋白酶F是一种最近进化的半胱氨酸蛋白酶，它不属于组织蛋白酶L或F亚家族中的任何一个。这种蛋白质兼具组织蛋白酶F和L的特征，并且它与其最接近的同源物的系统发育关系较远，包括同一亚家族中亲缘关系密切的线虫的蛋白质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/da1318db58b3/10.1177_1176934320962521-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/a5a6b8ef9931/10.1177_1176934320962521-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/31ce2f993e07/10.1177_1176934320962521-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/7b1784a662a7/10.1177_1176934320962521-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/4e31ff446c84/10.1177_1176934320962521-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/d33712c2b417/10.1177_1176934320962521-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/08f0bef847b0/10.1177_1176934320962521-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/8b2eaf44f2d6/10.1177_1176934320962521-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/78f70e1938dc/10.1177_1176934320962521-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/da1318db58b3/10.1177_1176934320962521-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/a5a6b8ef9931/10.1177_1176934320962521-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/31ce2f993e07/10.1177_1176934320962521-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/7b1784a662a7/10.1177_1176934320962521-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/4e31ff446c84/10.1177_1176934320962521-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/d33712c2b417/10.1177_1176934320962521-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/08f0bef847b0/10.1177_1176934320962521-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/8b2eaf44f2d6/10.1177_1176934320962521-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/78f70e1938dc/10.1177_1176934320962521-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed8c/7549167/da1318db58b3/10.1177_1176934320962521-fig9.jpg

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