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针对非酒精性脂肪肝治疗的肠道-肝脏轴和脂肪组织-肝脏轴的中草药：古代智慧与现代科学。

Chinese Medicinal Herbs Targeting the Gut-Liver Axis and Adipose Tissue-Liver Axis for Non-Alcoholic Fatty Liver Disease Treatments: The Ancient Wisdom and Modern Science.

机构信息

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

出版信息

Front Endocrinol (Lausanne). 2020 Sep 30;11:572729. doi: 10.3389/fendo.2020.572729. eCollection 2020.

DOI:10.3389/fendo.2020.572729
PMID:33101207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7556113/
Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. The pathogenesis of NAFLD is complex. Frontline western medicines only ameliorate the symptoms of NAFLD. On the contrary, the uniqueness of Chinese medicine in its interpretation of NAFLD and the holistic therapeutic approach lead to a promising therapeutic efficacy. Recent studies reveal that the gut-liver axis and adipose tissue-liver axis play important roles in the development of NAFLD. Interestingly, with advanced technology, many herbal formulae are found to target the gut-liver axis and adipose tissue-liver axis and resolve the inflammation in NAFLD. This is the first review summarizes the current findings on the Chinese herbal formulae that target the two axes in NAFLD treatment. This review not only demonstrates how the ancient wisdom of Chinese medicine is being interpreted by modern pharmacological studies, but also provides valuable information for the further development of the herbal-based treatment for NAFLD.

摘要

非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病之一。NAFLD 的发病机制复杂，一线西药仅能改善 NAFLD 的症状，而中医药对 NAFLD 的独特诠释和整体治疗方法具有潜在的治疗效果。最近的研究表明，肠-肝轴和脂肪组织-肝轴在 NAFLD 的发生发展中起重要作用。有趣的是，随着先进技术的发展，许多中草药方剂被发现可以针对肠-肝轴和脂肪组织-肝轴，从而缓解 NAFLD 的炎症。这是第一篇综述，总结了目前针对 NAFLD 治疗中这两个轴的中草药配方的研究结果。该综述不仅展示了现代药理学研究是如何对中医的古老智慧进行诠释的，还为基于草药的 NAFLD 治疗的进一步发展提供了有价值的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b138/7556113/0fafd60b2ea6/fendo-11-572729-g005.jpg
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