Lim Darosa, Landon-Cardinal Océane, Belisle Annie, Davar Sandra
Division of Dermatology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
Department of Medicine, University of Montreal, Division of Rheumatology and Research Center, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.
SAGE Open Med Case Rep. 2020 Oct 10;8:2050313X20961977. doi: 10.1177/2050313X20961977. eCollection 2020.
Dermatomyositis is an inflammatory myopathy presenting with characteristic cutaneous eruption and may be accompanied by proximal muscle weakness. Dermatomyositis may represent a paraneoplastic syndrome in 15%-25% of cases and has rarely been associated with endometrial cancer. Herein, we report a case of dermatomyositis with anti-TIF1γ antibodies as the first clinical manifestation revealing isolated para-aortic lymphadenopathy metastatic recurrence of endometrial cancer after 4 years of remission. Interestingly, dermatomyositis rash completely resolved after lymphadenectomy. This case highlights the importance of early dermatomyositis diagnosis, thorough cancer screening, and that cancer treatment may, in some patients, foster dermatomyositis remission.
皮肌炎是一种伴有特征性皮肤疹的炎性肌病，可能伴有近端肌无力。在15%-25%的病例中，皮肌炎可能是一种副肿瘤综合征，很少与子宫内膜癌相关。在此，我们报告一例以抗TIF1γ抗体为首发临床表现的皮肌炎病例，该病例显示在缓解4年后出现孤立的主动脉旁淋巴结转移复发的子宫内膜癌。有趣的是，淋巴结切除术后皮肌炎皮疹完全消退。该病例强调了早期诊断皮肌炎、全面癌症筛查的重要性，以及在某些患者中癌症治疗可能促进皮肌炎缓解。
