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功能性酸奶旨在预防大鼠黄曲霉毒素B1中毒。

Functional yogurt aims to protect against the aflatoxin B1 toxicity in rats.

作者信息

Abdel-Salam Ahmed M, Badr Ahmed Noah, Zaghloul Ahmed H, Farrag Abdel Razik H

机构信息

Dairy Science Department, National Research Centre, Dokki, Cairo, Egypt.

Food Toxicology and Contaminants Department, National Research Centre, Dokki, 12622, Cairo, Egypt.

出版信息

Toxicol Rep. 2020 Oct 21;7:1412-1420. doi: 10.1016/j.toxrep.2020.10.012. eCollection 2020.

Abstract

Recently, the rise of mycotoxin contamination in food materials was found to be due to several factors, including climatic changes' impact. Therefore, the aim of this study was to provide a novel food product that allows the reduction of aflatoxin impact in animal tissues. Chicory root-extract (CRE) was evaluated for its active components, antioxidant potency, and antimicrobial activity. The CRE was utilized to produce functional yogurt (FY) that was evaluated using experimental rats. The CRE showed high antioxidant activity and recorded valuable content of the active components. Results also showed a high antimicrobial effect against toxigenic fungal strains. The results have reflected the efficiency of the FY to suppress aflatoxin impacts in the animal tissues and biochemical parameters of rats-serum. An enhancement was recorded inliver and kidney functions for rats taking FY with the presence of aflatoxin. It was concluded that consumption of the FY assisted in suppression of the oxidative stress in rats-tissues.

摘要

最近发现,食品原料中霉菌毒素污染的增加是由多种因素造成的,包括气候变化的影响。因此,本研究的目的是提供一种新型食品,以减少黄曲霉毒素对动物组织的影响。对菊苣根提取物(CRE)的活性成分、抗氧化能力和抗菌活性进行了评估。利用CRE制作了功能性酸奶(FY),并使用实验大鼠对其进行了评估。CRE表现出高抗氧化活性,且活性成分含量可观。结果还显示出对产毒真菌菌株有很高抗菌效果。结果反映出FY在抑制黄曲霉毒素对动物组织及大鼠血清生化参数影响方面的有效性。在有黄曲霉毒素存在的情况下,食用FY的大鼠肝脏和肾脏功能有所增强。得出的结论是,食用FY有助于抑制大鼠组织中的氧化应激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b9c/7578531/f6bbf95ffc03/ga1.jpg

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