Gestrich Catherine K, Zhou Yi Yuan, Ravishankar Sanjita
Department of Pathology, University Hospitals Cleveland Medical Center/Case Western Reserve University, Cleveland, Ohio.
Pediatr Dev Pathol. 2021 Jan-Feb;24(1):47-50. doi: 10.1177/1093526620961352. Epub 2020 Oct 26.
Cytomegalovirus (CMV) infection is one of the most common congenital viral infections. Classically associated placental findings include chronic villitis with plasma cells, stromal hemosiderin deposition, and identification of viral inclusions in villous endothelial and stromal cells. We present a case of confirmed congenital CMV infection that lacked these classical findings, but demonstrated massive perivillous fibrin deposition (MPVFD). This is the first report of CMV associated with MPVFD. MPVFD is an uncommon placental lesion associated with adverse fetal outcomes and a high risk of recurrence. However, the recurrence risk in patients with an infectious cause may be lower in than patients with other associated clinical conditions.
巨细胞病毒（CMV）感染是最常见的先天性病毒感染之一。典型的相关胎盘表现包括伴有浆细胞的慢性绒毛炎、间质含铁血黄素沉积，以及在绒毛内皮细胞和间质细胞中发现病毒包涵体。我们报告一例确诊的先天性CMV感染病例，该病例缺乏这些典型表现，但显示有大量绒毛周围纤维蛋白沉积（MPVFD）。这是CMV与MPVFD相关的首例报告。MPVFD是一种罕见的胎盘病变，与不良胎儿结局及高复发风险相关。然而，感染性病因患者的复发风险可能低于其他相关临床情况的患者。
