Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine.
Department of Psychology, Guang An Men Hospital, China Academy of Chinese Medical Sciences.
Neuroreport. 2020 Dec 9;31(17):1215-1224. doi: 10.1097/WNR.0000000000001534.
Music and instruction-guided relaxation (MIGR) is a complementary therapeutic tool used in the treatment of the major depressive disorder (MDD). However, the neural mechanism that underlies the effect of MIGR on MDD patients is not known. Twenty-three right-handed MDD patients and 23 age-, sex-, handedness-, and educational level-matched healthy controls were enrolled. Resting-state functional MRI data were acquired from patients before and after MIGR and from healthy controls. The relationships between insular subregion-based functional connectivity and Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale (HAM-A), Automatic Thoughts Questionnaire, and Ruminative Responses Scale scores were examined. One-way analysis of variance exhibited significant differences among the three groups in functional connectivity between the left dorsal anterior insula (dAI) and left superior medial frontal gyrus (SMFG), left dAI and left precuneus, left posterior insula and left gyrus rectus, right ventral anterior insula (vAI) and left posterior cingulate cortex (PCC), right vAI and right inferior frontal gyrus (R-IFG). Further comparisons in regions of interest showed that MDD patients before MIGR showed decreased functional connectivity between the left dAI and left SMFG, left dAI and left precuneus, left posterior insula, and left gyrus rectus, right vAI and left PCC, right vAI and R-IFG relative to those in healthy controls. The strength of functional connectivity between the right dAI and left putamen also exhibited a negative correlation with the HAM-A score in MDD cases before MIGR. MIGR may result in enhanced functional connectivity in insular subregions, thereby potentially increasing the regulatory influence of cognitive reappraisal.
音乐和指导放松（MIGR）是一种用于治疗重度抑郁症（MDD）的补充治疗工具。然而，MIGR 对 MDD 患者的影响的神经机制尚不清楚。招募了 23 名右利手 MDD 患者和 23 名年龄、性别、惯用手和教育水平匹配的健康对照者。从 MIGR 前后的患者和健康对照者获得静息状态功能磁共振成像数据。检查了岛叶亚区功能连接与汉密尔顿抑郁评定量表、汉密尔顿焦虑评定量表（HAM-A）、自动思维问卷和沉思反应量表评分之间的关系。单因素方差分析显示，三组之间存在功能连接的显著差异，包括左背侧前岛叶（dAI）与左额上回（SMFG）、左 dAI 与左楔前叶、左后岛叶与左直回、右腹侧前岛叶（vAI）与左后扣带回（PCC）、右 vAI 与右额下回（R-IFG）。进一步在感兴趣的区域进行比较，结果显示，MIGR 前的 MDD 患者与健康对照组相比，左 dAI 与左 SMFG、左 dAI 与左楔前叶、左后岛叶和左直回、右 vAI 与左 PCC、右 vAI 与 R-IFG 之间的功能连接减弱。MIGR 可能导致岛叶亚区的功能连接增强，从而潜在地增加认知重评的调节影响。
