Nong Kate, Zhang Yue, Liu Shengyong, Yang Yue, Sun Donglin, Chen Xuemin
Department of Hepatopancreatobiliary Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
J Int Med Res. 2020 Jul;48(7):300060520943422. doi: 10.1177/0300060520943422.
To analyse potential risk factors for postoperative pancreatic fistula (POPF).
A retrospective study on risk factors for POPF was conducted in patients undergoing laparoscopic pancreatoduodenectomy. Basic characteristics, and preoperative, intraoperative and postoperative patient data were collected and analysed.
A total of 268 patients were enrolled in this study, including 54 patients with POPF following surgery (POPF incidence, 20.15%). Univariate analysis indicated that patient's age, body mass index (BMI), preoperative bilirubin level, pancreas texture, and drainage fluid amylase level on day 1 following surgery were associated with POPF. Multiple logistic regression analysis indicated that preoperative bilirubin level ≥170 µmol/l, soft pancreas texture, BMI ≥25, and age ≥65 years were independent risk factors associated with POPF.
For patients with preoperative bilirubin level ≥170 µmol/l, soft pancreas texture, BMI ≥25 and age ≥65 years, clinically relevant measures should be taken as early as possible for the prophylaxis of POPF.
分析术后胰瘘（POPF）的潜在危险因素。
对接受腹腔镜胰十二指肠切除术的患者进行POPF危险因素的回顾性研究。收集并分析患者的基本特征以及术前、术中和术后的数据。
本研究共纳入268例患者，其中术后发生POPF的患者有54例（POPF发生率为20.15%）。单因素分析表明，患者年龄、体重指数（BMI）、术前胆红素水平、胰腺质地以及术后第1天引流液淀粉酶水平与POPF有关。多因素logistic回归分析表明，术前胆红素水平≥170 µmol/l、胰腺质地柔软、BMI≥25以及年龄≥65岁是与POPF相关的独立危险因素。
对于术前胆红素水平≥170 µmol/l、胰腺质地柔软、BMI≥25且年龄≥65岁的患者，应尽早采取临床相关措施预防POPF。
