Chen Hai-Xia, Wu Yan-Ping, Li Wen, Shen Hua-Hao, Chen Zhi-Hua
Key Laboratory of Respiratory Diseases of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
Sheng Li Xue Bao. 2020 Oct 25;72(5):575-585.
Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.
铁死亡是一种新型的程序性细胞死亡形式，它依赖于铁和活性氧（ROS），并与脂质过氧化物的积累有关。在形态学、生物化学、遗传学等方面，它明显不同于其他细胞死亡类型。此外，它与铁催化的脂质过氧化物的产生有关，这是由非酶促或酶促反应引发的。铁死亡已被证明与血液系统疾病、心脑血管疾病、肝肾疾病有关。本文将综述铁死亡的定义、机制、诱导因子以及铁死亡在呼吸系统中的作用。我们期望为呼吸系统研究提出一个新的概念，并为呼吸系统疾病的临床预防和治疗提供潜在靶点。
