Meenakshi S Swarna, Malaiappan Sankari
Department of Periodontics, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.
Indian J Dent Res. 2020 Jul-Aug;31(4):593-600. doi: 10.4103/ijdr.IJDR_227_18.
Melatonin is an indolamine that is primarily secreted by the pineal gland. It has immunomodulatory as well as antioxidant properties. It is a potent anti-oxidant that protects against inflammation and cellular damage caused by reactive oxygen species, also has potent angiogenic function that adds on to the benefits of melatonin. As a result of these actions, melatonin may be useful as an adjuvant in the treatment of various conditions in the oral cavity. The aim of this study is to systematically evaluate the role of melatonin in periodontal disease.
An extensive review of the scientific literature was carried out using PubMed, Science Direct, Google Scholar and the Cochrane base. Research articles were collected upto December 2017.
Melatonin may have beneficial effects in certain inflammatory oral pathologies, mainly periodontal diseases where they inhibit bone resorption destroy reactive oxygen species, stimulates osteoblastic differentiation. Salivary melatonin could also act as a risk indicator for periodontal diseases.
Many studies showed that the melatonin levels in GCF, Saliva, Serum of patients suffering from chronic periodontitis is lowered suggesting that may play a pivotal role in protecting the tissue from damage caused by oxidative stress. However, there exists no data on the concentration needed, method of application for potential benefits. Randomized clinical trials in this field are needed to fill the lacunae and better improve our understanding.
褪黑素是一种主要由松果体分泌的吲哚胺。它具有免疫调节和抗氧化特性。它是一种强大的抗氧化剂，可防止活性氧引起的炎症和细胞损伤，还具有强大的血管生成功能，这进一步增加了褪黑素的益处。由于这些作用，褪黑素可能作为辅助药物用于治疗口腔中的各种病症。本研究的目的是系统评价褪黑素在牙周病中的作用。
使用PubMed、Science Direct、谷歌学术和考克兰图书馆对科学文献进行广泛检索。收集截至2017年12月的研究文章。
褪黑素可能对某些炎性口腔疾病有益，主要是在牙周病中，它可抑制骨吸收、清除活性氧、刺激成骨细胞分化。唾液褪黑素也可作为牙周病的风险指标。
许多研究表明，慢性牙周炎患者龈沟液、唾液、血清中的褪黑素水平降低，提示其可能在保护组织免受氧化应激损伤方面起关键作用。然而，关于所需浓度、潜在益处的应用方法尚无数据。该领域需要进行随机临床试验以填补空白并更好地增进我们的理解。
