Anttila L, Ruutiainen K, Erkkola R
Department of Obstetrics and Gynecology, Turku University Central Hospital, Finland.
Ann Chir Gynaecol Suppl. 1987;202:32-4.
Clinical and laboratory studies were performed in 18 hirsute women for evaluation of the efficacy of spironolactone (S) therapy. Each patient received S 100 mg daily. The grade of hirsutism was assessed using a semiquantitative scale of Ferriman and Gallwey. Total testosterone, androstendione, dehydroepiandrosterone sulphate and sexhormone binding globulin were measured before initiation and after six months of therapy. A clinical response was seen in 12 women. The total score of hirsutism in the whole patient group was decreased from 14.1 +/- 6.3 (mean +/- S.D.) to 11.8 +/- 6.4 (p less than 0.01). No changes were found in the hormonal values. The findings of the present study confirm the efficacy of S in decreasing the hair growth by mainly a peripheral mode of action.
对18名多毛症女性进行了临床和实验室研究，以评估螺内酯（S）治疗的疗效。每位患者每天服用100毫克S。使用费里曼和高尔韦半定量量表评估多毛症的严重程度。在治疗开始前和治疗六个月后，测量总睾酮、雄烯二酮、硫酸脱氢表雄酮和性激素结合球蛋白。12名女性出现了临床反应。整个患者组的多毛症总分从14.1±6.3（平均值±标准差）降至11.8±6.4（p<0.01）。激素值未发现变化。本研究结果证实了S主要通过外周作用模式减少毛发生长的疗效。
