[Digestive hormones and the colon].

The distribution of neuropeptides at the level of the colon is similar to that observed in other parts of the digestive tract, with, however, specific elements, such as the predominance of enteroglucagon and somatostatin cells. These substances regulate, on the one hand, the function of colonic absorption-secretion, and, on the other hand, the motor function. The control exerted by these substances on sodium absorption and chloride secretion, is done through two metabolic systems depending on the AMPc level for one, and the intra-cellular calcium for the other. Neuro-hormonal peptides modulate the metabolic response through specific receptors and regulating proteins, activating and inhibiting. These same substances, acting either directly one smooth muscle, or indirectly through activating or inhibiting interneurons, share in the control of colon motility.