Tsuruo T
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research.
Gan To Kagaku Ryoho. 1987 Oct;14(10):2809-15.
The development of suitable screening systems is one of the most important determinants for the successful discovery of new anti-tumor drugs. The National Cancer Institute, U.S.A. has been playing a major role in the discovery and development of new agents by using various animal tumor models since 1955. In this article, the historical overview of this effort, and the difficulties and problems of this approach was reviewed. Also the new "Disease-Oriented Screening System", which is now under development as a new screening system at the National Cancer Institute was also described.
合适筛选系统的开发是成功发现新型抗肿瘤药物的最重要决定因素之一。自1955年以来，美国国立癌症研究所一直在利用各种动物肿瘤模型在新药物的发现和开发中发挥主要作用。在本文中，回顾了这项工作的历史概况以及这种方法的困难和问题。此外，还描述了美国国立癌症研究所正在开发的作为一种新筛选系统的新型“以疾病为导向的筛选系统”。
