Department of HPB Surgery, University Hospitals of Leicester, UK.
Dietetics Department, University Hospitals of Leicester, UK.
Pancreatology. 2020 Dec;20(8):1661-1666. doi: 10.1016/j.pan.2020.10.041. Epub 2020 Oct 22.
-To assess the efficacy of a pilot Chronic Pancreatitis (CP) Multidisciplinary (MDT) clinic.
-The average age was 51.27 (±12.75). The commonest aetiology was alcohol (55%). Ninety one point five percent had evidence of ongoing pancreatic exocrine insufficiency, with 88.1% requiring initiation or up-titration of pancreatic enzyme replacement (PERT). Up to half of the patients exhibited micronutrient deficiency. Twenty eight percent were diagnosed with type IIIc diabetes. There was an average daily reduction of 6 mg of morphine usage per patient with a concurrent decline in median pain scores from 83.3 to 63.3, which was non-significant. The median QoL score was 33.3 compared to a score of 75 from the reference population. QoL scores increased from 31.0 to 37.3 at follow up appointments. Seventy two point five percent of patients had undiagnosed low BMD.
The data suggest that CP patients have significant nutritional deficiencies as well as undiagnosed diabetes, poor pain and glycaemic control which negatively impacts QoL. Assessment in a multi-disciplinary clinic ensures appropriate management.
-评估慢性胰腺炎(CP)多学科(MDT)诊所的疗效。
-分析了 60 名转诊至试点 MDT CP 诊所的患者。检查了人体测量数据、营养状况、吸收不良证据、血糖控制、阿片类药物使用、骨密度(BMD)评估和生活质量(QoL)。
-平均年龄为 51.27(±12.75)。最常见的病因是酒精(55%)。91.5%的患者有持续的胰腺外分泌功能不全的证据,其中 88.1%需要开始或增加胰酶替代治疗(PERT)。多达一半的患者存在微量营养素缺乏。28%的患者被诊断为 IIIc 型糖尿病。每位患者的吗啡用量平均每天减少 6 毫克,同时中位数疼痛评分从 83.3 降至 63.3,但无统计学意义。中位 QoL 评分为 33.3,而参考人群的评分为 75。在随访时,QoL 评分从 31.0 增加到 37.3。72.5%的患者患有未确诊的低 BMD。
数据表明 CP 患者存在严重的营养缺乏以及未确诊的糖尿病、疼痛和血糖控制不佳,这对 QoL 产生负面影响。在多学科诊所进行评估可确保进行适当的管理。