Epidemiology Branch,
Biostatistics and Bioinformatics Branch, and.
Pediatrics. 2020 Nov;146(5). doi: 10.1542/peds.2020-0857.
To identify homogenous depressive symptom trajectories over the postpartum period and the demographic and perinatal factors linked to different trajectories.
Mothers ( = 4866) were recruited for Upstate KIDS, a population-based birth cohort study, and provided assessments of depressive symptoms at 4, 12, 24, and 36 months postpartum. Maternal demographic and perinatal conditions were obtained from vital records and/or maternal report.
Four depression trajectories were identified: low-stable (74.7%), characterized by low symptoms at all waves; low-increasing (8.2%), characterized by initially low but increasing symptoms; medium-decreasing (12.6%), characterized by initially moderate but remitting symptoms; and high-persistent (4.5%), characterized by high symptoms at all waves. Compared with the high-persistent group, older mothers (maximum odds ratio [OR] of the 3 comparisons: 1.10; 95% confidence interval [CI]: 1.05 to 1.15) or those with college education (maximum OR: 2.52; 95% CI: 1.36 to 4.68) were more likely to be in all other symptom groups, and mothers who had a history of mood disorder (minimum OR: 0.07; 95% CI: 0.04 to 0.10) or gestational diabetes mellitus diagnosis (minimum OR: 0.23; 95% CI: 0.08 to 0.68) were less likely to be in other symptom groups. Infertility treatment, multiple births, prepregnancy BMI, gestational hypertension, and infant sex were not differentially associated with depressive symptom trajectories.
One-quarter of mothers in a population-based birth cohort had elevated depressive symptoms in 3 years postpartum. Screening for maternal depression beyond the postpartum period may be warranted, particularly after mood and diabetic disorders.
确定产后期间同质抑郁症状轨迹以及与不同轨迹相关的人口统计学和围产期因素。
招募了 4866 名母亲参加基于人群的 Upstate KIDS 出生队列研究,并在产后 4、12、24 和 36 个月时对其抑郁症状进行评估。从生命记录和/或母亲报告中获取产妇人口统计学和围产期状况。
确定了四种抑郁轨迹:低稳定型(74.7%),所有波次均表现为低症状;低递增型(8.2%),最初表现为低症状但逐渐增加;中递减型(12.6%),最初表现为中度但缓解症状;高持续型(4.5%),所有波次均表现为高症状。与高持续型组相比,年龄较大的母亲(3 组比较的最大优势比[OR]:1.10;95%置信区间[CI]:1.05 至 1.15)或具有大学学历的母亲(最大 OR:2.52;95% CI:1.36 至 4.68)更有可能处于其他所有症状组中,而患有心境障碍病史的母亲(最小 OR:0.07;95% CI:0.04 至 0.10)或妊娠期糖尿病诊断的母亲(最小 OR:0.23;95% CI:0.08 至 0.68)不太可能处于其他症状组中。不孕治疗、多胎妊娠、孕前 BMI、妊娠期高血压和婴儿性别与抑郁症状轨迹无差异相关。
在一个基于人群的出生队列中,有四分之一的母亲在产后 3 年内出现了升高的抑郁症状。可能需要在产后期间进行产妇抑郁筛查,特别是在出现情绪和糖尿病障碍之后。