Garretson B R, Robertson D M, Earle J D
Department of Ophthalmology, Mayo Clinic, Rochester, Minn 55905.
Arch Ophthalmol. 1987 Oct;105(10):1394-7. doi: 10.1001/archopht.1987.01060100096035.
Twenty-six patients were treated for malignant melanoma of the choroid with iodine 125 episcleral plaques. Patients were followed up for at least two years, with a mean follow-up of 45 months. Tumor shrinkage was documented by A-scan ultrasonography in all but one patient. The average reduction in tumor thickness was 46%. Visual acuity remained within two Snellen lines of preoperative levels in 14 (54%) of the 26 patients. Of the 12 patients who lost more than two lines of central visual acuity, eight developed radiation changes affecting either the optic nerve or retina, and three developed cataracts; enucleation accounted for the loss of vision in the final patient. Enucleation was necessary in one other patient in this series because of tumor growth. The mean duration between treatment with iodine 125 and the development of radiation changes affecting the optic nerve or retina was 32 months.
26例脉络膜恶性黑色素瘤患者接受了碘125巩膜外斑块治疗。患者随访至少两年，平均随访45个月。除1例患者外，所有患者均通过A超记录到肿瘤缩小。肿瘤厚度平均减少46%。26例患者中有14例（54%）的视力保持在术前水平的两个斯内伦视力行数范围内。在12例中心视力丧失超过两行的患者中，8例出现影响视神经或视网膜的放射性改变，3例出现白内障；最后1例患者失明是由于眼球摘除。该系列中的另1例患者因肿瘤生长而需要进行眼球摘除。碘125治疗至出现影响视神经或视网膜的放射性改变的平均时间为32个月。
