Mandal Moumita, Dasgupta Aparajita, Dutt Debashis, Taraphdar Pranita, Ghosh Parasar, Paul Bobby
Department of Preventive and Social Medicine, All India Institute of Hygiene and Public Health, Kolkata, West Bengal, India.
Public Health Administration, All India Institute of Hygiene and Public Health, Kolkata, West Bengal, India.
J Family Med Prim Care. 2020 Aug 25;9(8):3970-3976. doi: 10.4103/jfmpc.jfmpc_53_20. eCollection 2020 Aug.
Rheumatoid arthritis (RA) is a known chronic debilitating disease accounting for a large percentage of disability globally. Pain and stiffness, decreased work function, depression and emotional state alteration, fatigue, disability, and social handicaps are some patient reported outcomes, which if considered with priority the health-related quality of life (HRQOL) of patients with RA could improve.
This study was conducted with the aim to assess the HRQOL of the patients with RA and the determinants related to it.
This was a cross-sectional study conducted at Rheumatology Department of a tertiary care hospital, Kolkata.
A total of 252 patients with RA were selected in this study through systematic random sampling.
Data were analyzed using appropriate statistical measures with Statistical Package for the Social Sciences(SPSS) version 16.0 (Armonk, NY: IBM Corporation) software program, version 16.0. Univariate and multivariable logistic regression were carried out.
In the study, the mean age of the patients was 43.1 years (mean age ±SD: 43.05±10.63 years). The proportion of female subjects was 84.5%. Unsatisfactory QOL was found in 59.9% study participants. In multivariable logistic regression unsatisfactory quality of life was significantly associated to moderate to high functional disability [AOR: 6.04, CI: 2.86, 12.78], disease activity moderate to high [AOR: 5.41, CI: 1.87, 15.69], presence of comorbidity [AOR: 2.90, CI: 1.39, 6.04], extra-articular manifestations [AOR: 3.14, CI: 1.41, 6.96] and delay in starting Disease-Modifying Anti-Rheumatoid Drugs (DMARDs) [AOR: 1.24, CI: 1.08, 1.42].
Findings of this study clearly indicate the presence of high proportion of unsatisfactory QOL among the patients with RA. Early identification and prompt referral are the key strategies to prevent any permanent damage. Regular follow-up of the patients should be carried out to prevent or delay the disability progression and provide high-quality physical and mental health.
类风湿性关节炎（RA）是一种已知的慢性致残性疾病，在全球致残病例中占很大比例。疼痛和僵硬、工作功能下降、抑郁和情绪状态改变、疲劳、残疾以及社会障碍是一些患者报告的结果，如果优先考虑这些因素，类风湿性关节炎患者的健康相关生活质量（HRQOL）可能会得到改善。
本研究旨在评估类风湿性关节炎患者的健康相关生活质量及其相关决定因素。
这是一项在加尔各答一家三级护理医院的风湿病科进行的横断面研究。
本研究通过系统随机抽样共选取了252例类风湿性关节炎患者。
使用社会科学统计软件包（SPSS）16.0版（纽约州阿蒙克：IBM公司）的适当统计方法对数据进行分析，版本为16.0。进行了单变量和多变量逻辑回归分析。
在本研究中，患者的平均年龄为43.1岁（平均年龄±标准差：43.05±10.63岁）。女性受试者的比例为84.5%。59.9%的研究参与者生活质量不满意。在多变量逻辑回归分析中，生活质量不满意与中度至高度功能残疾显著相关[AOR：6.04，CI：2.86，12.78]、疾病活动度为中度至高度[AOR：5.41，CI：1.87，15.69]、合并症的存在[AOR：2.90，CI：1.39，6.04]、关节外表现[AOR：3.14，CI：1.41，6.96]以及开始使用改善病情抗风湿药物（DMARDs）的延迟[AOR：1.24，CI：1.08，1.42]。
本研究结果清楚地表明类风湿性关节炎患者中生活质量不满意的比例很高。早期识别和及时转诊是预防任何永久性损害的关键策略。应对患者进行定期随访，以预防或延缓残疾进展，并提供高质量的身心健康服务。
