Lebedev V S, Kuzovnikova T A, Kornev A P, Fedorov Iu I
Biofizika. 1987 Jul-Aug;32(4):638-41.
Copper dependent uptake of streptomycin by resting E. coli cells was studied. It was shown that copper stimulates the aminoglycoside uptake only when bacteria possess endogenic energy sources. Additional accumulation of positive charged molecules of the antibiotic is accompanied by partial depolarisation of the membrane, its steady state distribution between cells and the medium corresponding to the resulted value of the membrane potential. On the basis of the data obtained it was suggested that under the influence of copper membrane permeability for streptomycin increases.
研究了静止的大肠杆菌细胞对链霉素的铜依赖性摄取。结果表明，只有当细菌拥有内源性能量来源时，铜才会刺激氨基糖苷类药物的摄取。抗生素带正电荷分子的额外积累伴随着膜的部分去极化，其在细胞和培养基之间的稳态分布与膜电位的最终值相对应。根据获得的数据表明，在铜的影响下，膜对链霉素的通透性增加。
