Ajima Sayaka, Sano Yusuke, Hashizume Hideo
Department of Dermatology, Iwata City Hospital, Iwata, Japan.
J Dermatol. 2021 Mar;48(3):389-391. doi: 10.1111/1346-8138.15669. Epub 2020 Oct 28.
Ophthalmic quinolone preparations are widely used for the treatment of eye diseases; however, there are only a few reported cases of immediate hypersensitivity due to such medications. Here, we present a case of immediate hypersensitivity induced by an ophthalmic administration of quinolones in a 20-year-old female with bacterial conjunctivitis. The results of skin prick and basophil activation tests suggest that it involved a type Ib reaction associated with Mas-related G-protein coupled receptor X2. The present case cautions us to be aware of quinolone immediate hypersensitivity caused by topical ophthalmic preparations, which can easily be overlooked, because it may predict severe hypersensitivity reactions to systemic administration.
眼科喹诺酮制剂广泛用于治疗眼部疾病；然而，因这类药物引起速发型超敏反应的报道病例较少。在此，我们报告一例20岁患有细菌性结膜炎的女性因眼部使用喹诺酮类药物诱发速发型超敏反应的病例。皮肤点刺试验和嗜碱性粒细胞活化试验结果表明，该反应涉及与Mas相关G蛋白偶联受体X2相关的Ib型反应。本病例提醒我们要注意局部眼科制剂引起的喹诺酮速发型超敏反应，这种反应很容易被忽视，因为它可能预示着对全身给药会发生严重的超敏反应。
