Young N S, Leonard E, Platanias L
Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.
Blood Cells. 1987;13(1-2):87-100.
Clinical observations first suggested an immune basis for aplastic anemia. Laboratory studies have implicated a suppressor T lymphocyte producing molecules like gamma-interferon that inhibit hematopoiesis. Extrapolation from in vitro studies is complicated by synergy and antagonism among lymphokines and interleukins, the presence of regulators of proliferation produced by bone marrow cells, and possible differences between endogenous and exogenously administered molecules on cell growth.
临床观察首先提示再生障碍性贫血存在免疫基础。实验室研究表明，一种抑制性T淋巴细胞可产生如γ干扰素等抑制造血的分子。体外研究的推断因淋巴因子和白细胞介素之间的协同作用和拮抗作用、骨髓细胞产生的增殖调节因子的存在，以及内源性和外源性给药分子对细胞生长可能存在的差异而变得复杂。
