Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Department of Medical Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
Andrologia. 2021 Feb;53(1):e13833. doi: 10.1111/and.13833. Epub 2020 Oct 28.
Avanafil is a highly selective and potent oral phosphodiesterase type 5 inhibitor. However, its impact on the soluble markers of endothelial function has not been investigated yet. This study was conducted to assess the effect of daily avanafil on the endothelial markers' serum level and erectile function in patients with erectile dysfunction. In this work, we randomly divided 140 males with erectile dysfunction and other diseases commonly associated with endothelial dysfunction like diabetes mellitus, hypertension and dyslipidaemia into two equal groups: treatment group, treated with 50mg daily oral avanafil, and control group, treated with placebo. The International Index of Erectile Function-5 score and the serum levels of nitric oxide, cyclic guanosine monophosphate and endothelin-1 as markers of endothelial function were measured at baseline and after four weeks of treatment in both groups. At the end of treatment period, those randomised to avanafil achieved statistically significant improvement in erectile function, nitric oxide, cyclic guanosine monophosphate and endothelin-1 levels from baseline versus placebo regardless the type and duration of associated comorbidity as well as the duration and severity of erectile dysfunction. These results permitted us to suggest that daily avanafil can improve the impaired endothelial function associated with the erectile dysfunction.
阿伐那非是一种高度选择性和有效的口服磷酸二酯酶 5 抑制剂。然而，其对内皮功能可溶性标志物的影响尚未被研究过。本研究旨在评估每日服用阿伐那非对勃起功能障碍患者内皮标志物血清水平和勃起功能的影响。在这项工作中，我们将 140 名患有勃起功能障碍和其他常见与内皮功能障碍相关的疾病（如糖尿病、高血压和血脂异常）的男性随机分为两组：治疗组，每天口服 50mg 阿伐那非治疗；对照组，给予安慰剂治疗。在两组中，均在基线和治疗 4 周后测量国际勃起功能指数-5 评分和血清一氧化氮、环磷酸鸟苷和内皮素-1 水平作为内皮功能的标志物。在治疗期末，与安慰剂相比，随机分配到阿伐那非组的患者在勃起功能、一氧化氮、环磷酸鸟苷和内皮素-1 水平方面均有统计学显著改善，无论合并症的类型和持续时间以及勃起功能障碍的持续时间和严重程度如何。这些结果表明，每日服用阿伐那非可以改善与勃起功能障碍相关的受损内皮功能。
