维生素 D 受体基因的遗传多态性与泰国东北部宫颈癌风险相关。
Genetic Polymorphisms of Vitamin D Receptor Gene are Associated with Cervical Cancer Risk in Northeastern Thailand.
机构信息
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
出版信息
Asian Pac J Cancer Prev. 2020 Oct 1;21(10):2935-2939. doi: 10.31557/APJCP.2020.21.10.2935.
OBJECTIVE
This study aimed to explore whether VDR polymorphisms (Fok1, Apa1 and Taq1) are associated to the cervical cancer in Thai population.
MATERIALS AND METHODS
Subjects of 204 cervical cancer patient and 204 age-matched healthy control were enrolled in the case-control study. VDR polymorphisms were detected by using real-time PCR. Haplotype analysis of three loci was applied to the obtained genotypes.
RESULTS
Significantly increased risk for cervical cancer was observed in carriers of TT genotype (p = 0.0388) and T allele (p = 0.0357) of Fok1 and TC genotype (p = 0.0001), CC genotype (p = 0.0160) and the C allele of Taq1 (p = 0.0001). Haplotype analyses revealed a significant correlation between C-T-C, T-G-C and T-T-C haplotypes and elevated risk for cervical cancer (OR = 2.06; 95%CI = 1.06-4.00; p = 0.0313, OR = 2.15; 95%CI = 1.22-3.80; p = 0.0078 and OR = 2.81; 95%CI = 1.53-5.16; p = 0.0006, respectively). Furthermore, haplotype carrying C allele of Taq1 (C-G-C + C-T-C + T-G-C + T-T-C) significantly increased cervical cancer risk with OR of 1.92 (95%CI = 1.32-2.79, p = 0.0006).
CONCLUSION
Our finding revealed an association between VDR polymorphisms and cervical cancer risk. Taq1 C allele might be a molecular marker for cervical cancer development.
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目的
本研究旨在探讨维生素 D 受体（VDR）多态性（Fok1、Apa1 和 Taq1）是否与泰国人群的宫颈癌相关。
材料与方法：采用病例对照研究，纳入 204 例宫颈癌患者和 204 例年龄匹配的健康对照者。采用实时 PCR 检测 VDR 多态性。对获得的基因型进行三个位点的单体型分析。
结果：Fok1 的 TT 基因型（p = 0.0388）和 T 等位基因（p = 0.0357）、TC 基因型（p = 0.0001）、CC 基因型（p = 0.0160）和 Taq1 的 C 等位基因携带者宫颈癌发病风险显著增加（p = 0.0388）。单体型分析显示，C-T-C、T-G-C 和 T-T-C 单体型与宫颈癌发病风险显著相关（OR = 2.06；95%CI = 1.06-4.00；p = 0.0313，OR = 2.15；95%CI = 1.22-3.80；p = 0.0078 和 OR = 2.81；95%CI = 1.53-5.16；p = 0.0006）。此外，Taq1 携带 C 等位基因的单体型（C-G-C+C-T-C+T-G-C+T-T-C）显著增加宫颈癌发病风险，OR 为 1.92（95%CI = 1.32-2.79，p = 0.0006）。
结论：本研究结果表明，VDR 多态性与宫颈癌风险相关。Taq1 C 等位基因可能是宫颈癌发生的分子标志物。
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