Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, California.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota.
AIDS Educ Prev. 2020 Oct;32(5):378-391. doi: 10.1521/aeap.2020.32.5.378.
The aim of the study was to investigate the relationship between counseling prior to starting antiretroviral treatment (ART) and adherence to treatment among women enrolled in Option B+ in Zambia. Using convenience sampling, 150 HIV+ women enrolled in an Option B+ treatment regimen in rural and urban districts were recruited. Four generalized Poisson regression models were built to assess the association between counseling and adherence to ART. In all, 75% of the participants reported adherence in the past 7 days. In adjusted analyses, there was a significant positive relationship between counseling and adherence in the rural district (prevalence ratio [PR] 2.52, 95% CI [1.19, 5.35], = 81) but not in the urban district (PR = 0.77, 95% CI [0.15, 3.91], = 69). Offering counseling prior to initiating antiretroviral treatment to HIV+ women is particularly important for promoting medication adherence in rural settings of low resourced countries.
本研究旨在探讨赞比亚实施 B+方案中，接受抗逆转录病毒治疗（ART）前咨询与患者治疗依从性之间的关系。采用便利抽样法，在农村和城市地区招募了 150 名接受 B+治疗方案的 HIV 阳性女性。构建了四个广义泊松回归模型来评估咨询与 ART 治疗依从性之间的关联。总体而言，75%的参与者报告在过去 7 天内有服药依从性。在调整分析中，在农村地区咨询与依从性之间存在显著的正相关关系（患病率比 [PR] 2.52，95%置信区间 [1.19，5.35]， = 81），而在城市地区无此关联（PR = 0.77，95%置信区间 [0.15，3.91]， = 69）。在资源匮乏国家的农村地区，为 HIV 阳性女性提供抗逆转录病毒治疗前咨询对于促进药物依从性尤为重要。
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