12310Penn State College of Medicine Medical Scientist Training Program, Hershey, PA, USA.
12310Penn State College of Medicine, University Park, PA, USA.
J Child Neurol. 2021 Mar;36(4):324-330. doi: 10.1177/0883073820968995. Epub 2020 Oct 28.
Since the first reports of SARS-CoV-2 infection from China, multiple studies have been published regarding the epidemiologic aspects of COVID-19 including clinical manifestations and outcomes. The majority of these studies have focused on respiratory complications. However, recent findings have highlighted the systemic effects of the virus, including its potential impact on the nervous system. Similar to SARS-CoV-1, cellular entry of SARS-CoV-2 depends on the expression of ACE2, a receptor that is abundantly expressed in the nervous system. Neurologic manifestations in adults include cerebrovascular insults, encephalitis or encephalopathy, and neuromuscular disorders. However, the presence of these neurologic findings in the pediatric population is unclear. In this review, the potential neurotropism of SARS-CoV-2, known neurologic manifestations of COVID-19 in children, and management of preexisting pediatric neurologic conditions during the COVID-19 pandemic are discussed.
自中国首次报告 SARS-CoV-2 感染以来，已有多项研究发表，涉及 COVID-19 的流行病学方面，包括临床表现和结局。这些研究大多集中在呼吸道并发症上。然而，最近的发现强调了该病毒的全身影响，包括其对神经系统的潜在影响。与 SARS-CoV-1 类似，SARS-CoV-2 的细胞进入依赖于 ACE2 的表达，ACE2 是一种在神经系统中大量表达的受体。成人的神经系统表现包括脑血管损伤、脑炎或脑病以及神经肌肉疾病。然而，这些神经系统表现是否存在于儿科人群中尚不清楚。在这篇综述中，我们讨论了 SARS-CoV-2 的潜在神经嗜性、儿童 COVID-19 的已知神经系统表现以及 COVID-19 大流行期间对儿科现有神经系统疾病的管理。
