Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Genome Engineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
PLoS One. 2020 Oct 28;15(10):e0240191. doi: 10.1371/journal.pone.0240191. eCollection 2020.
Functional analyses of genes are crucial for unveiling biological responses, genetic engineering, and developing new medicines. However, functional analyses have largely been restricted to model organisms, representing a major hurdle for functional studies and industrial applications. To resolve this, comparative genome analyses can be used to provide clues to gene functions as well as their evolutionary history. To this end, we present Prometheus, a web-based omics portal that contains more than 17,215 sequences from prokaryotic and eukaryotic genomes. This portal supports interkingdom comparative analyses via a domain architecture-based gene identification system and Gene Search, and users can easily and rapidly identify single or entire gene sets in specific pathways. Bioinformatics tools for further analyses are provided in Prometheus or through Bio-Express, a cloud-based bioinformatics analysis platform. Prometheus is a new paradigm for comparative analyses of large amounts of genomic information.
功能分析对于揭示生物反应、基因工程和开发新药至关重要。然而，功能分析在很大程度上仅限于模式生物，这是功能研究和工业应用的主要障碍。为了解决这个问题，可以利用比较基因组分析来提供基因功能及其进化历史的线索。为此，我们提出了 Prometheus，这是一个基于网络的组学门户，其中包含了来自原核和真核基因组的超过 17215 个序列。该门户通过基于结构域的基因识别系统和 Gene Search 支持种间比较分析，用户可以轻松快速地识别特定途径中的单个或整个基因集。Prometheus 或通过基于云的生物信息学分析平台 Bio-Express 提供了用于进一步分析的生物信息学工具。Prometheus 是对大量基因组信息进行比较分析的新范例。
