Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Anatomy, Addis Ababa University, Addis Ababa, Ethiopia.
PLoS One. 2020 Oct 28;15(10):e0240353. doi: 10.1371/journal.pone.0240353. eCollection 2020.
Precancerous lesions of the cervix are changes in cervical cells that make them more likely to develop into cancer. Understanding the prevalence and determinants of the precancerous lesions of the cervix among women helps to take an action like vaccination programs, improving screening coverage, and close management and follow-up which could decrease the morbidity and mortality caused by cervical cancer.
The international databases, PubMed/MEDLINE, Web of Science, EMBASE, CINAHL, Google Scholar, Science Direct and Cochrane Library and unpublished reports were systematically searched. Two authors independently extracted all necessary data using a standardized data extraction format. STATA 14 statistical software was employed to analyse the data. The Cochrane Q test statistics and I2 tests were used to assess the heterogeneity between the studies. A random-effect model was computed to estimate the pooled prevalence of precancerous lesions of the cervix in Ethiopia. Determinants of the precancerous lesion of cervix (early initiation of sexual intercourse, multiple sexual partners, and history of sexually transmitted infection) were analysed.
Thirteen studies fulfilled the inclusion criteria and included in the meta-analysis. The I2 test result showed high heterogeneity (I2, 93.2%, p = <0.001). Using the random effect analysis, the pooled prevalence of precancerous lesions of the cervix among women in Ethiopia was 14.21% (95% CI (10.49, 17.94). After adjusting of publication bias using trim-and-fill method, the pooled prevalence was 9.43% (95% CI (5.23, 13.62). Women who had multiple sexual partners in their lifetime (OR:2.67 CI: 1.49,4.79) and had a history of sexually transmitted infections (OR:6.22 CI: 2.99,12.92) were more likely to have a precancerous lesion of the cervix.
The pooled prevalence of the precancerous lesions of the cervix among Ethiopian women was 9.43%. It was associated with having multiple sexual partners and a history of sexually transmitted infections.
宫颈前病变是指宫颈细胞发生的变化，使它们更有可能发展为癌症。了解宫颈前病变在女性中的流行率和决定因素有助于采取行动，如接种疫苗计划、提高筛查覆盖率以及密切管理和随访，这可以降低宫颈癌引起的发病率和死亡率。
系统检索了国际数据库PubMed/MEDLINE、Web of Science、EMBASE、CINAHL、Google Scholar、Science Direct 和 Cochrane Library 以及未发表的报告。两位作者使用标准化的数据提取格式独立提取所有必要数据。使用 STATA 14 统计软件分析数据。Cochrane Q 检验统计量和 I2 检验用于评估研究之间的异质性。使用随机效应模型估计埃塞俄比亚宫颈前病变的 pooled 患病率。分析了宫颈前病变的决定因素（性开始过早、多个性伴侣和性传播感染史）。
符合纳入标准的 13 项研究被纳入荟萃分析。I2 检验结果显示高度异质性（I2，93.2%，p<0.001）。使用随机效应分析，埃塞俄比亚妇女宫颈前病变的 pooled 患病率为 14.21%（95%CI（10.49，17.94）。使用 trim-and-fill 方法调整发表偏倚后，pooled 患病率为 9.43%（95%CI（5.23，13.62）。一生中具有多个性伴侣的女性（OR：2.67 CI：1.49，4.79）和有性传播感染史的女性（OR：6.22 CI：2.99，12.92）更有可能发生宫颈前病变。
埃塞俄比亚妇女宫颈前病变的 pooled 患病率为 9.43%。它与多个性伴侣和性传播感染史有关。
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