Department of Adult Health Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Department of Pediatrics and Child Health Nursing, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Syst Rev. 2021 Nov 1;10(1):287. doi: 10.1186/s13643-021-01840-0.
Though cervical cancer is largely preventable, it is still the second most common female cancer globally and the leading cause of cancer deaths among females in African. Though many efforts have been done to study the burden of the disease in Ethiopia, primary studies examining the prevalence of precancerous cervical lesions are fragmented. Hence, this systematic review and meta-analysis is aimed at estimating the pooled prevalence of precancerous cervical lesion and its trends in Ethiopia.
This systematic review and meta-analysis was conducted using the following electronic databases. PubMed, Web of Science, SCOPUS, Science Direct, Google Scholar, African Index Medicus (AIM), African Journals Online databases, and Addis Ababa and Bahir Dar Universities research repositories were searched following the Preferred Items for Systematic Review and Meta-analysis (PRISMA) Guideline. STATA 15 statistical software was used to analyze the data. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for meta-analysis. Heterogeneity between studies was assessed using the Cochrane Q test and I test statistics based on the random effects model. A random effects model was computed to estimate the pooled prevalence of precancerous cervical lesion in Ethiopia. Finally, the trend of precancerous cervical lesion in the country was presented.
Seventeen studies with a total of 26,112 participants were included in the analysis. The pooled prevalence of precancerous cervical lesion was 15.16 (95% CI 10.16-19.70). The subgroup analysis by region showed the highest prevalence of precancerous cervical lesion at the Southern Nations and Nationalities Peoples Region (19.65%; 95% CI 15.51-23.80). The trend of precancerous cervical lesion prevalence showed an increased pattern over time.
Approximately one among six of the study participants had precancerous cervical lesion. The trend also showed that there is still an increasing precancerous cervical lesion in Ethiopia. Best practices in achieving high vaccination coverage shall be informed by practices in other successful countries.
尽管宫颈癌在很大程度上是可以预防的，但它仍然是全球第二大常见的女性癌症，也是非洲女性癌症死亡的主要原因。尽管已经做出了许多努力来研究埃塞俄比亚的疾病负担，但检查癌前宫颈病变患病率的主要研究仍然很零散。因此，本系统评价和荟萃分析旨在估计埃塞俄比亚癌前宫颈病变的总体患病率及其趋势。
本系统评价和荟萃分析使用以下电子数据库进行。根据《系统评价和荟萃分析首选项目 (PRISMA) 指南》，在 PubMed、Web of Science、SCOPUS、Science Direct、Google Scholar、非洲医学索引 (AIM)、非洲期刊在线数据库以及亚的斯亚贝巴和巴赫达尔大学研究存储库中进行了搜索。使用 STATA 15 统计软件分析数据。使用 Joanna Briggs 研究所 (JBI) 循证卫生保健中心质量评估工具评估纳入研究的质量。使用 Cochrane Q 检验和基于随机效应模型的 I 检验统计量评估研究之间的异质性。使用随机效应模型估计埃塞俄比亚癌前宫颈病变的总体患病率。最后，呈现了该国癌前宫颈病变的趋势。
纳入了 17 项研究，共 26112 名参与者。癌前宫颈病变的总体患病率为 15.16%（95%CI 10.16-19.70）。按地区进行的亚组分析显示，南部各族人民地区的癌前宫颈病变患病率最高，为 19.65%（95%CI 15.51-23.80）。癌前宫颈病变患病率的趋势表明，随着时间的推移呈上升趋势。
大约六分之一的研究参与者患有癌前宫颈病变。该趋势还表明，埃塞俄比亚的癌前宫颈病变仍在增加。在实现高疫苗接种覆盖率方面的最佳做法应借鉴其他成功国家的做法。
