Mori T, Fukawa O, Sato T, Hori S
No Shinkei Geka. 1977 Jul;5(8):865-9.
Current chemotherapy of malignant brain tumor bases on cell kinetics. Chemotherapeutic agents are devided into two, cell cycle specific (CCS) and cell cycle non specific (CCNS) agents. A case of malignant glioma successfully treated by chemo-radiotherapy using a new combination of the two agents , Carboquone (CQ) as CCNS, which has not appeared in literature, and FT-207 as CCS is reported. A malignant glioma in the right frontal lobe in a case of 51-year-old male was removed subtotaly on Dec. 10th, 1971 in our clinic. Three years and five months after the surgery, the patient was diagnosed as having a recurred malignant glioma in the left frontal lobe from the clinical symptoms. This was supported by a positive brain scan and carotid angiography. A total dose of 57mg of CQ was continuously into the left internal carotid artery during two months. Simultaneously, 16g of FT-207 as a total dose was given orally and 4,550 rads of Telecobalt-60 were irradiated. One month after the beginning of these treatments, clinical symptoms improved obviously. Four months later, the size of the tumor shadow on the brain scan decreased remarkably and the shifted anterior cerebral artery returned to normal position on the carotid angiogram. Anemia, leucopenia, thrombocytopenia, nausea, and anorexia were the side-effects of these treatments. But these complications disappeared six weeks after the termination of the treatments.
当前恶性脑肿瘤的化疗基于细胞动力学。化疗药物分为两类，即细胞周期特异性（CCS）药物和细胞周期非特异性（CCNS）药物。本文报道了一例恶性胶质瘤患者，采用两种药物的新组合进行化疗放疗并取得成功，其中CCNS药物为卡波醌（CQ）（该药物在文献中未见报道），CCS药物为替加氟（FT - 207）。1971年12月10日，我院为一名51岁男性患者行右额叶恶性胶质瘤次全切除术。术后三年零五个月，根据临床症状，该患者被诊断为左额叶恶性胶质瘤复发。脑部扫描阳性及颈动脉血管造影结果支持这一诊断。两个月内，通过左颈内动脉持续注入总量为57mg的CQ。同时，口服给予总量为16g的FT - 207，并进行4550拉德的钴 - 60远距离照射。这些治疗开始一个月后，临床症状明显改善。四个月后，脑部扫描显示的肿瘤阴影大小显著减小，颈动脉血管造影显示移位的大脑前动脉恢复到正常位置。贫血、白细胞减少、血小板减少、恶心和厌食是这些治疗的副作用。但这些并发症在治疗结束六周后消失。
