Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, China.
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, China.
Biomed Pharmacother. 2020 Dec;132:110808. doi: 10.1016/j.biopha.2020.110808. Epub 2020 Oct 28.
Emerging evidence has shown that aberrantly expressed long noncoding RNAs (lncRNAs) play a vital role in various biological processes of tumorigenesis. Bladder cancer associated transcript 1 (BLACAT1) is a novel lncRNA located on chromosome 1q32.1, which regulated multiple downstream targets via serving as a "sponge" for their corresponding microRNAs or by directly interacting with various regulating proteins. In this review, we summarized the role of BLACAT1 in the development and progression of different cancers. We also highlighted that BLACAT1 could be utilized as a potential biomarker and therapeutic target for human cancers.
新兴证据表明，异常表达的长非编码 RNA（lncRNA）在肿瘤发生的各种生物学过程中发挥着重要作用。膀胱癌相关转录本 1（BLACAT1）是一种位于 1q32.1 染色体上的新型 lncRNA，可通过充当相应 microRNA 的“海绵”或直接与各种调节蛋白相互作用，来调节多个下游靶标。在这篇综述中，我们总结了 BLACAT1 在不同癌症的发生和发展中的作用。我们还强调，BLACAT1 可以作为人类癌症的潜在生物标志物和治疗靶点。
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