Clinique Interdisciplinaire de Mémoire, CHU de Québec/Université Laval/Hôpital de l'Enfant-Jésus, Québec, Québec, Canada.
Département de Réadaptation, Faculté de Médecine, Université Laval, Québec, Québec, Canada.
Dement Geriatr Cogn Disord. 2020;49(4):410-417. doi: 10.1159/000510501. Epub 2020 Oct 28.
BACKGROUND/AIMS: The logopenic variant of primary progressive aphasia (lvPPA) is characterized by impaired word-finding and sentence repetition with phonologic errors but spared motor speech and grammar and semantic knowledge. Although its language deficits have been well studied, the full spectrum of cognitive changes in the lvPPA remains to be defined. We aimed to explore the neurocognitive profile of the lvPPA using a newly developed cognitive screening tool for atypical dementias, the Dépistage Cognitif de Québec (DCQ).
We compared 29 patients with lvPPA to 72 amnestic variant Alzheimer disease (aAD) to 438 healthy control (HC) participants. Performance on the 5 indexes of the DCQ (Memory, Visuospatial, Executive, Language and Behavioral) was compared between the 3 groups.
Results showed a significantly lower performance for lvPPA participants in all neurocognitive domains, when compared to HC. When compared to aAD, lvPPA participants had significantly lower scores for language, executive, and visuospatial abilities, but not for memory and behavior.
Altogether, these findings better define the neurocognitive changes of lvPPA.
背景/目的：以言语流畅性降低为主要表现的原发性进行性失语症（lvPPA）的特征是找词困难和句子复述伴有语音错误，但运动言语和语法以及语义知识不受影响。尽管其语言缺陷已得到充分研究，但 lvPPA 的认知变化全貌仍有待确定。我们旨在使用新开发的用于非典型性痴呆的认知筛查工具——魁北克认知筛查工具（DCQ）来探讨 lvPPA 的神经认知特征。
我们比较了 29 例 lvPPA 患者、72 例遗忘型阿尔茨海默病（aAD）患者和 438 例健康对照（HC）参与者的认知表现。比较了 3 组患者在 DCQ 的 5 个指标（记忆、视空间、执行、语言和行为）上的表现。
结果显示，与 HC 相比，lvPPA 患者在所有神经认知领域的表现明显降低。与 aAD 相比，lvPPA 患者在语言、执行和视空间能力方面的得分明显较低，但在记忆和行为方面没有差异。
总的来说，这些发现更好地定义了 lvPPA 的神经认知变化。
