Irrespective of the degree of hyperlactatemia, similar lactate levels were associated with a lower mortality rate in metformin users compared with non-users: beware of confounders!
作者信息
Honore Patrick M, Barreto Gutierrez Leonel, Kugener Luc, Redant Sebastien, Attou Rachid, Gallerani Andrea, De Bels David
机构信息
ICU Dept., Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Place Van Gehuchtenplein, 4, 1020, Brussels, Belgium.
出版信息
Ann Intensive Care. 2020 Oct 28;10(1):148. doi: 10.1186/s13613-020-00766-5.
Abstract
摘要
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Irrespective of the degree of hyperlactatemia, similar lactate levels were associated with a lower mortality rate in metformin users compared with non-users: beware of confounders!无论高乳酸血症的程度如何，与非使用者相比，二甲双胍使用者中相似的乳酸水平与较低的死亡率相关：谨防混杂因素！
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本文引用的文献
1
Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study.乳酸水平升高对接受和未接受入院前二甲双胍治疗的危重症患者死亡率的预后影响：一项基于丹麦登记处的队列研究。
Ann Intensive Care. 2020 Mar 26;10(1):36. doi: 10.1186/s13613-020-00652-0.
2
Lactic acidosis and severe septic shock in metformin users: a cohort study.二甲双胍使用者中的乳酸酸中毒与严重脓毒症休克：一项队列研究。
Crit Care. 2016 Jan 15;20:10. doi: 10.1186/s13054-015-1180-6.
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Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup.体外治疗二甲双胍中毒：来自体外中毒治疗工作组的系统评价和建议。
Crit Care Med. 2015 Aug;43(8):1716-30. doi: 10.1097/CCM.0000000000001002.
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Management of metformin-associated lactic acidosis by continuous renal replacement therapy.连续性肾脏替代疗法治疗二甲双胍相关性乳酸酸中毒。
PLoS One. 2011;6(8):e23200. doi: 10.1371/journal.pone.0023200. Epub 2011 Aug 11.
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Metformin-associated lactic acidosis in an intensive care unit.重症监护病房中与二甲双胍相关的乳酸性酸中毒
Crit Care. 2008;12(6):R149. doi: 10.1186/cc7137. Epub 2008 Nov 26.
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