Vizioli Jacopo, Verri Tiziano, Pagliara Patrizia
Inserm, Univ.Lille, Inserm, U1192-Protéomique Réponse Inflammatoire Spectrométrie de Masse-PRISM, F-59000 Lille, France.
Dipartimento di Scienze e Tecnologie Biologiche e Ambientali, Università del Salento, Via Provinciale Lecce-Monteroni, 73100 Lecce, Italy.
Biology (Basel). 2020 Oct 24;9(11):355. doi: 10.3390/biology9110355.
Allograft inflammatory factor-1 (AIF-1) is a calcium-binding scaffold/adaptor protein often associated with inflammatory diseases. Originally cloned from active macrophages in humans and rats, this gene has also been identified in other vertebrates and in several invertebrate species. Among metazoans, AIF-1 protein sequences remain relatively highly conserved. Generally, the highest expression levels of are observed in immunocytes, suggesting that it plays a key role in immunity. In mammals, the expression of has been reported in different cell types such as activated macrophages, microglial cells, and dendritic cells. Its main immunomodulatory role during the inflammatory response has been highlighted. Among invertebrates, is involved in innate immunity, being in many cases upregulated in response to biotic and physical challenges. transcripts result ubiquitously expressed in all examined tissues from invertebrates, suggesting its participation in a variety of biological processes, but its role remains largely unknown. This review aims to present current knowledge on the role and modulation of and to highlight its function along the evolutionary scale.
同种异体移植炎症因子-1（AIF-1）是一种钙结合支架/衔接蛋白，常与炎症性疾病相关。该基因最初是从人类和大鼠的活化巨噬细胞中克隆出来的，在其他脊椎动物和几种无脊椎动物物种中也已被鉴定出来。在后生动物中，AIF-1蛋白序列保持相对高度保守。一般来说，在免疫细胞中观察到其最高表达水平，这表明它在免疫中起关键作用。在哺乳动物中，已报道其在不同细胞类型中表达，如活化巨噬细胞、小胶质细胞和树突状细胞。其在炎症反应中的主要免疫调节作用已得到强调。在无脊椎动物中，它参与固有免疫，在许多情况下，对生物和物理刺激会上调表达。AIF-1转录本在无脊椎动物所有检测组织中均普遍表达，表明其参与多种生物学过程，但其作用在很大程度上仍不清楚。本综述旨在介绍关于AIF-1作用和调节的当前知识，并突出其在进化尺度上的功能。
