Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Obstetrics and Gynecology, TOYOTA Memorial Hospital, Toyota, Japan.
Drug Discov Ther. 2020 Nov 4;14(5):232-238. doi: 10.5582/ddt.2020.03078. Epub 2020 Oct 29.
The objective of this study was to explore the factors associated symptoms of depression among pregnant women with gestational diabetes mellitus (GDM) in Japan. This cross-sectional study was conducted at a hospital in Toyota, Japan, from January 2015 to June 2016. Pregnant women who visited the hospital and were diagnosed with GDM in the second trimester were enrolled. We analyzed depression symptoms using the Centers for Epidemiological Studies Depression Scale (CES-D) and considered related factors of depression symptoms, such as dietary intake and daily walking. Dietary intake during the past month was assessed using a brief self-administered diet history questionnaire, and daily walking was assessed using an accelerometer. The prevalence rate for GDM was 8.8%, and 25 pregnant women with GDM were analyzed. The CES-D was not significantly correlated with pre-pregnancy BMI, postprandial plasma glucose, hemoglobin A1c, and the number of steps walked. In contrast, a significant negative correlation was observed between the CES-D score and intake of fish with bones, simmered fish, pickles, green leaves, mushrooms, and green tea. Furthermore, a significant positive correlation was found between Coke and CES-D scores. For nutrient intake, a significant negative correlation was found between the CES-D score and vitamin K, folate, and β-carotene levels. The present study suggests that depression symptoms among pregnant women with GDM in the second trimester may be associated with diet.
本研究旨在探讨日本妊娠期糖尿病（GDM）孕妇抑郁症状的相关因素。这项横断面研究于 2015 年 1 月至 2016 年 6 月在日本丰田的一家医院进行。招募了在医院就诊并在妊娠中期被诊断为 GDM 的孕妇。我们使用流行病学研究中心抑郁量表（CES-D）分析抑郁症状，并考虑与抑郁症状相关的因素，如饮食摄入和日常步行。过去一个月的饮食摄入量通过简短的自我管理饮食史问卷进行评估，日常步行通过加速度计进行评估。GDM 的患病率为 8.8%，对 25 名患有 GDM 的孕妇进行了分析。CES-D 与孕前 BMI、餐后血糖、血红蛋白 A1c 和步数均无显著相关性。相比之下，CES-D 评分与带骨鱼类、炖鱼、腌制食品、绿叶蔬菜、蘑菇和绿茶的摄入量呈显著负相关。此外，Coke 和 CES-D 评分之间存在显著正相关。对于营养素摄入，CES-D 评分与维生素 K、叶酸和β-胡萝卜素水平呈显著负相关。本研究表明，妊娠中期 GDM 孕妇的抑郁症状可能与饮食有关。
