炎性乳腺癌的生物标志物：诊断及治疗效用
Biomarkers for Inflammatory Breast Cancer: Diagnostic and Therapeutic Utility.
作者信息
Dobiasova Barbora, Mego Michal
机构信息
2 Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak Republic.
出版信息
Breast Cancer (Dove Med Press). 2020 Oct 14;12:153-163. doi: 10.2147/BCTT.S231502. eCollection 2020.
Inflammatory breast cancer (IBC) is a rare and highly aggressive subtype of advanced breast cancer. The aggressive behavior, resistance to chemotherapy, angiogenesis, and high metastatic potential are key intrinsic characteristics of IBC caused by many specific factors. Pathogenesis and behavior of IBC are closely related to tumor surrounding inflammatory and immune cells, blood vessels, and extracellular matrix, which are all components of the tumor microenvironment (TME). The tumor microenvironment has a crucial role in the local immune r09esponse. The communication between intrinsic and extrinsic components of IBC and the abundance of cytokines and chemokines in the TME strongly contribute to the aggressiveness and high angiogenic potential of this tumor. Critical modes of interaction are cytokine-mediated communication and direct intercellular contact between cancer cells and tumor microenvironment with a variety of pathway crosstalk. This review aimed to summarize current knowledge of predictive and prognostic biomarkers in IBC.
炎性乳腺癌（IBC）是一种罕见且侵袭性很强的晚期乳腺癌亚型。侵袭性行为、化疗耐药性、血管生成和高转移潜能是由多种特定因素导致的IBC的关键内在特征。IBC的发病机制和行为与肿瘤周围的炎性和免疫细胞、血管以及细胞外基质密切相关，这些都是肿瘤微环境（TME）的组成部分。肿瘤微环境在局部免疫反应中起关键作用。IBC内在和外在成分之间的相互作用以及TME中细胞因子和趋化因子的丰富程度极大地促成了这种肿瘤的侵袭性和高血管生成潜能。关键的相互作用模式是细胞因子介导的通讯以及癌细胞与肿瘤微环境之间通过多种信号通路串扰进行的直接细胞间接触。本综述旨在总结目前关于IBC中预测性和预后生物标志物的知识。
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