三种二取代[13]-大环二内酯的结构揭示了取代对大环构象的影响。
Structures of three disubstituted [13]-macro-di-lac-tones reveal effects of substitution on macrocycle conformation.
作者信息
Rutledge Kelli M, Griesbach Caleb, Mercado Brandon Q, Peczuh Mark W
机构信息
Department of Chemistry, University of Connecticut, 55 N. Eagleville Road, U3060, Storrs, CT 06269, USA.
Department of Chemistry, Yale University, PO Box 208107, New Haven, CT 06520, USA.
出版信息
Acta Crystallogr E Crystallogr Commun. 2020 Sep 8;76(Pt 10):1617-1623. doi: 10.1107/S2056989020012037. eCollection 2020 Oct 1.
The synthesis and crystal structures of three new disubstituted [13]-macro-di-lactones, namely, -4,8-dimethyl-1,10-dioxa-cyclo-tridec-5-ene-2,9-dione, CHO, , -4-(4-bromo-phen-yl)-13-methyl-1,10-dioxa-cyclo-tridec-5-ene-2,9-dione CHBrO, , and -11-methyl-4-phenyl-1,10-dioxa-cyclo-tridec-5-ene-2,9-dione, CHO, , are reported and their conformations are put in the context of other [13]-macrodilactone structures reported previously. Together, they show that the number, location, and relative disposition of groups attached at the termini of planar units of the [13]-macrodilactones subtly influence their aspect ratios.
报道了三种新型二取代[13]-大环二内酯的合成及晶体结构，即 -4,8-二甲基-1,10-二氧杂环十三碳-5-烯-2,9-二酮（CHO）、 -4-(4-溴苯基)-13-甲基-1,10-二氧杂环十三碳-5-烯-2,9-二酮（CHBrO）和 -11-甲基-4-苯基-1,10-二氧杂环十三碳-5-烯-2,9-二酮（CHO），并将它们的构象与先前报道的其他[13]-大环二内酯结构进行了对比。综合来看，它们表明[13]-大环二内酯平面单元末端连接基团的数量、位置和相对排布会对其长宽比产生微妙影响。
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