Patel Vipul, Majumdar Tilottama, Samreen Isha, Grewal Harpreet, Kaleekal Thomas
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Newark Beth Israel Medical Center, New Jersey, 07112, USA.
Respir Med Case Rep. 2020 Oct 10;31:101242. doi: 10.1016/j.rmcr.2020.101242. eCollection 2020.
Patients with cystic fibrosis (CF) have increased life span because of improved care over last 50 years. With increasing survival, predisposition of cancer may become evident. We have observed increase risk of gastrointestinal tract cancer, testicular cancer and lymphoid leukemia. Lung cancer in patients with CF is rare. Our patient developed chronic respiratory failure due to CF related bronchiectasis. Patient had progressive disease despite optimum treatment, requiring lung transplantation. Pathology of explant lung showed focus of invasive adenocarcinoma of lung origin. Patient had no evidence of lung carcinoma recurrence in one year. To our knowledge this is the fourth reported lung cancer case in a patient with CF.
由于过去50年护理水平的提高，囊性纤维化（CF）患者的寿命有所延长。随着存活率的提高，患癌倾向可能会变得明显。我们观察到胃肠道癌、睾丸癌和淋巴样白血病的风险增加。CF患者患肺癌很罕见。我们的患者因CF相关支气管扩张发展为慢性呼吸衰竭。尽管进行了最佳治疗，患者病情仍进展，需要进行肺移植。移植肺的病理显示有肺源性浸润性腺癌灶。患者在一年内无肺癌复发迹象。据我们所知，这是第四例报道的CF患者患肺癌的病例。
