Wang Guannan, Xu Zhiwei, Zhu Jie, Ren Jiayu, Chen Mina, He Guijuan, Yu Beibei
Blood Purification Center, Ningbo Medical Center, Lihuili Hospital, Ningbo, China.
Department of Critical Care Medicine, Ningbo Medical Center, Lihuili Hospital, Ningbo, China.
Front Public Health. 2020 Oct 6;8:551490. doi: 10.3389/fpubh.2020.551490. eCollection 2020.
An increasing incidence of pancreatic cancer has been observed worldwide over the last few decades. Previous reports suggested that hay fever, a common allergic disease, may function in pancreatic cancer. Data on hay fever as a risk or protective factor for pancreatic cancer was controversial in several case-control reports. So, we here did a meta-analysis on published studies to evaluate the association of hay fever and the risk of pancreatic cancer. A comprehensive literature search was performed through public databases. The association between hay fever and pancreatic cancer was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). The Cochran's Q test and I index were used to evaluate heterogeneity. We included 8 population-based case-control studies involving 10,454 participants from 1986 to 2014. A history of hay fever was associated with a decreased risk of pancreatic cancer (OR, 0.57; 95% CI, 0.50-0.64, < 0.00001) through fixed effect model. The result of our study suggested that hay fever may significantly decrease the risk of pancreatic cancer.
在过去几十年间，全球范围内胰腺癌的发病率呈上升趋势。先前的报告表明，花粉症作为一种常见的过敏性疾病，可能与胰腺癌有关。在一些病例对照研究中，关于花粉症是胰腺癌的风险因素还是保护因素的数据存在争议。因此，我们在此对已发表的研究进行荟萃分析，以评估花粉症与胰腺癌风险之间的关联。通过公共数据库进行了全面的文献检索。花粉症与胰腺癌之间的关联通过比值比（OR）和95%置信区间（CI）进行评估。采用 Cochr an's Q检验和I指数评估异质性。我们纳入了8项基于人群的病例对照研究，涉及1986年至2014年的10454名参与者。通过固定效应模型，花粉症病史与胰腺癌风险降低相关（OR，0.57；95%CI，0.50 - 0.64，<0.00001）。我们的研究结果表明，花粉症可能显著降低胰腺癌的风险。
