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3D 打印药物的各个方面。

Aspects of 3D printed drugs.

机构信息

Department of Mechanical Engineering, DIT University, Dehradun, India.

出版信息

J Med Eng Technol. 2020 Nov;44(8):472-480. doi: 10.1080/03091902.2020.1822942. Epub 2020 Oct 29.

Abstract

Three-dimensional (3D) printing is an additive manufacturing technique where objects are created under computer control. Apart from opening many avenues of manufacturing, 3D printing of medicine has become a lucrative area in research. The technology can deliver customised and effectively on-demand treatments for individuals with unique needs; drug delivery system capable of dispensing spatially accurate and low volumes of medicine; preparation of medicine comprised of complex composition and geometric shape. Advent of 3D printed drugs like Spritam has been FDA approved which have heightened the hopes. Pharmaceutical industry at present is shifting from mass production to personalised medicine as it promises future production of on-demand printed drugs with customised doses, increased productivity and cost-effectiveness. The goal of this article is to outline and explore the various approaches, along with the key aspects of drug printing, and also allow space for exploration of the main areas of 3D printing to be tackled in the future in order to make it an effective manufacturing route for the pharmaceutical industry.

摘要

三维(3D)打印是一种增材制造技术,在计算机控制下创建物体。除了为制造业开辟了许多途径外,医学 3D 打印也成为了研究的一个有利可图的领域。该技术可以为具有独特需求的个人提供定制和有效按需治疗;药物输送系统能够分配空间准确和低体积的药物;制备由复杂成分和几何形状组成的药物。3D 打印药物如 Spritam 的出现已获得 FDA 批准,这提高了人们的期望。目前,制药行业正从大规模生产向个性化医疗转变,因为它有望未来生产按需打印的药物,具有定制剂量、提高生产力和成本效益。本文的目的是概述和探讨各种方法,以及药物打印的关键方面,并为探索未来 3D 打印的主要领域留出空间,以便使其成为制药行业有效的制造途径。

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