利用 3D 打印技术开发药物产品：从传统到新型药物传递系统。

Pharmaceutical Product Development Exploiting 3D Printing Technology: Conventional to Novel Drug Delivery System.

机构信息

Research and Development, Jamjoom Pharmaceuticals, Jeddah 21442, Saudi Arabia.

School of Bioscience and Technology, VIT University, Vellore - 632 014, Tamilnadu, India.

出版信息

Curr Pharm Des. 2018;24(42):5029-5038. doi: 10.2174/1381612825666190206195808.

DOI:10.2174/1381612825666190206195808

PMID:30727872

Abstract

BACKGROUND

3D printed pharmaceutical products are revolutionizing the pharmaceutical industry as a prospective mean to achieve a personalized method of treatments acquired to the specially designed need of each patient. It will depend upon age, weight, concomitants, pharmacogenetics and pharmacokinetic profile of the patient and thus transforming the current pharmaceutical market as a potential alternative to conventional medicine. 3D printing technology is getting more consideration in new medicine formulation development as a modern and better alternative to control many challenges associated with conventional medicinal products. There are many advantages of 3D printed medicines which create tremendous opportunities for improving the acceptance, accuracy and effectiveness of these medicines. In 2015, United State Food and Drug Administration has approved the first 3D printed tablet (Spritam®) and had shown the emerging importance of this technology.

METHODS

This review article summarizes as how in-depth knowledge of drugs and their manufacturing processes can assist to manage different strategies for various 3D printing methods. The principal goal of this review is to provide a brief introduction about the present techniques employed in tech -medicine evolution from conventional to a novel drug delivery system.

RESULTS

It is evidenced that through its unparalleled advantages of high-throughput, versatility, automation, precise spatial control and fabrication of hierarchical structures, the implementation of 3D printing for the expansion and delivery of controlled drugs acts as a pivotal role.

CONCLUSION

3D printing technology has an extraordinary ability to provide elasticity in the manufacturing and designing of composite products that can be utilized in programmable and personalized medicine. Personalized medicine helps in improving drug safety and minimizes side effects such as toxicity to individual human being which is associated with unsuitable drug dose.

摘要

背景

3D 打印制药产品正在改变制药行业，成为一种有前途的方法，可以根据每个患者的特殊需求实现个性化治疗。它将取决于患者的年龄、体重、伴随疾病、药物遗传学和药物代谢动力学特征，从而改变当前的医药市场，成为传统医学的潜在替代品。3D 打印技术在新药制剂开发中越来越受到关注，作为一种控制与传统医药产品相关的许多挑战的现代且更好的替代方法。3D 打印药品具有许多优势，为提高这些药品的可接受性、准确性和有效性创造了巨大机会。2015 年，美国食品和药物管理局批准了第一种 3D 打印片剂（Spritam®），这表明了这项技术的重要性日益凸显。