Department of Medical Biochemistry and Biophysics, Umeå University, Umeå 90187, Sweden.
Chem Commun (Camb). 2020 Nov 25;56(91):14251-14254. doi: 10.1039/d0cc05483f. Epub 2020 Oct 29.
Phen-DC is among the most commonly used G-quadruplex (G4)-stabilizers in vitro and in cells. Here, we show that the G4-interactive binding interactions enable one to tune the optical properties of Phen-DC allowing the detection of G4 structures in cancer cells. This work opens up new directions for the use of Phen-DC as a selective G4 fluorescent reporter.
Phen-DC 是体外和细胞中最常用的 G-四链体 (G4)-稳定剂之一。在这里，我们表明 G4 相互作用的结合相互作用能够调整 Phen-DC 的光学性质，从而允许在癌细胞中检测 G4 结构。这项工作为将 Phen-DC 用作选择性 G4 荧光报告物开辟了新的方向。
