Albisser A M, Nomura M, Schulz M, Bahoric A, Kubota M, Holland F J
Division of Biomedical Research, Hospital for Sick Children, Toronto, Ontario, Canada.
Horm Metab Res. 1987 Aug;19(8):348-52. doi: 10.1055/s-2007-1011821.
This study was undertaken to explore the physiological relationships between fasting glycemia, antecedent glycemic control and fasting growth hormone levels in pancreatectomized dogs. In contrast to other studies, we used continuous intravenous infusions of insulin in an attempt not only to normalize fasting plasma glycemia but also to eliminate the characteristic fluctuations of diabetes usually encountered in the postprandial and postabsorptive periods. For comparison, a similar group of healthy animals served as normal controls. In the healthy dogs, fasting growth hormone (GH) levels were stable and well within normal limits for this species, demonstrating an overall mean +/- SD of 2.50 +/- 0.46 ng/ml. In the pancreatectomized group as a whole, the fasting GH levels were significantly elevated (4.63 +/- 2.42 ng/ml, P less than 0.01) and significantly (P less than 0.001) more variable than in the controls. Multiple regression and analysis of variance confirmed the expected significant positive correlation between fasting GH and fasting plasma glucose levels, but also elucidated a heretofore unknown direct relationship between fasting GH levels and the preceding instability of glycemic control.
本研究旨在探讨胰腺切除犬的空腹血糖、既往血糖控制情况与空腹生长激素水平之间的生理关系。与其他研究不同的是，我们采用胰岛素持续静脉输注，不仅试图使空腹血糖正常化，还试图消除通常在餐后和吸收后阶段出现的糖尿病特征性波动。作为对照，一组相似的健康动物作为正常对照组。在健康犬中，空腹生长激素（GH）水平稳定，且在该物种的正常范围内，总体平均值±标准差为2.50±0.46 ng/ml。在整个胰腺切除组中，空腹GH水平显著升高（4.63±2.42 ng/ml，P<0.01），且与对照组相比差异显著（P<0.001），变异性更大。多元回归和方差分析证实了空腹GH与空腹血糖水平之间预期的显著正相关，但也阐明了空腹GH水平与既往血糖控制不稳定之间迄今未知的直接关系。
