Fung Mavis M Y, Choi Kai Yip, Chan Henry H L
The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Ophthalmic Physiol Opt. 2021 Jan;41(1):171-178. doi: 10.1111/opo.12751. Epub 2020 Oct 29.
To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG).
Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0-8°), para-macular (8-18°) and peri-macular (18-30°) regions, and then compared across the three conditions using two-way, repeated measures ANOVA.
Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition.
Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced.
研究同步双焦点（DF）对通过全视野闪光多焦视网膜电图（mfERG）测量的视网膜活动的影响。
招募30名成年人，在三种情况下进行mfERG测量：聚焦状态（即无散焦）、+2.50 D DF和+7.50 D DF，分别使用单焦点隐形眼镜和双焦点镜片。mfERG的直接成分（DC）和诱发成分（IC）被汇总到中心黄斑区（0-8°）、黄斑旁区（8-18°）和黄斑周边区（18-30°），然后使用双向重复测量方差分析在三种情况下进行比较。
同步DF对IC振幅有显著影响，+7.50 D DF时的IC振幅显著强于聚焦状态（p < 0.01），主要来自中心和黄斑旁区域。+2.50 D DF条件下未观察到显著影响。
在相对较强的同步DF整合作用下，视网膜显示出增强的视网膜反应，该反应起源于视网膜内层。与黄斑周边区相比，中心和黄斑旁反应似乎增强。
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