Brown University, Providence, RI 02912, USA.
Neuron. 2020 Oct 28;108(2):259-269. doi: 10.1016/j.neuron.2020.10.015.
This Perspective examines the status of large-scale cortical interfaces through the lens of potential applications to active implants for brain-machine interfaces. Examples of research and development in a still embryonic field are discussed from a neuroengineer's perspective, touching on the design of scalable electrophysiological sensors with the ambition to access thousands of cortical points at near-cellular-level resolution. Important issues include microscale geometry of neural probes, design of implantable ultra-low-power electronics, implementation of high-data-rate wireless telemetry, and compatible device packaging-all requiring advanced solutions along a translational path for chronic human use.
本文从神经工程师的角度探讨了仍处于萌芽阶段的领域中的研究和开发范例，通过大规模皮质界面的潜在应用，考察了主动植入式脑机接口的现状。文中触及了可访问近细胞分辨率的数千个皮质点的可扩展电生理学传感器的设计，探讨了包括神经探针的微尺度几何形状、可植入式超低功耗电子设备的设计、高数据率无线遥测的实现以及兼容设备封装等重要问题，所有这些都需要沿着慢性人体使用的转化途径来提供先进的解决方案。
