小儿喉肉瘤：系统评价和汇总分析。

Pediatric laryngeal sarcoma: Systematic review and pooled analysis.

机构信息

Department of Otolaryngology-Head and Neck Surgery, Boston University Medical Center, Boston, MA, USA.

Boston University School of Medicine, Boston, MA, USA.

出版信息

Int J Pediatr Otorhinolaryngol. 2020 Dec;139:110471. doi: 10.1016/j.ijporl.2020.110471. Epub 2020 Oct 23.

DOI:10.1016/j.ijporl.2020.110471

PMID:33120103

Abstract

BACKGROUND

Sarcomas are a rare, diverse tumor class of mesenchymal origin affecting all age groups. Survival after diagnosis is influenced by disease site. To date, there are no analyses evaluating treatment of pediatric sarcoma within the larynx specifically.

METHODS

A structured literature review following PRISMA guidelines was preformed to identify case reports of pediatric (age 17 and younger) laryngeal sarcoma.

RESULTS

Twenty-nine case reports documenting 37 pediatric patients diagnosed with sarcoma in the larynx were identified since 1980. The majority of patients were male (79.4%). The most common histological subtypes were rhabdomyosarcoma (69.4%) and synovial sarcoma (19.4%). The supraglottis was the most common site of disease (62.1%) among laryngeal subsites. Only two patients were known to have succumbed to their disease. Overall survival was not statistically impacted by primary site of tumor, treatment strategy, histology or gender.

CONCLUSIONS

Soft tissue sarcoma is rarely found in the pediatric larynx. Patient and tumor characteristics studied were not shown to affect outcomes. Increased documenting of high-quality case reports is needed to advance understanding of this disease.

摘要

背景

肉瘤是一种罕见且多样化的间叶来源肿瘤，影响所有年龄段的人群。诊断后的存活率受疾病部位的影响。迄今为止，尚无专门针对儿童喉肉瘤治疗的分析。

方法

按照 PRISMA 指南进行了系统的文献回顾，以确定自 1980 年以来儿童（年龄在 17 岁及以下）喉肉瘤的病例报告。

结果

自 1980 年以来，共确定了 29 份病例报告，记录了 37 名儿童患者的诊断为喉肉瘤。大多数患者为男性（79.4%）。最常见的组织学亚型是横纹肌肉瘤（69.4%）和滑膜肉瘤（19.4%）。在喉的亚部位中，最常见的疾病部位是声门上区（62.1%）。仅两名患者死于该疾病。总体生存率不受肿瘤原发部位、治疗策略、组织学或性别影响。