Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark; Nykøbing Falster Hospital, Center for Epidemiological Research, Ejegodvej 63, DK-4800 Nykøbing, Denmark.
Environ Int. 2021 Jan;146:106202. doi: 10.1016/j.envint.2020.106202. Epub 2020 Oct 26.
Telomere length (TL) is a biomarker of biological aging that may be affected by prenatal exposure to air pollution. The aim of this study was to assess the association between prenatal exposure to air pollution and TL in maternal blood cells (leukocytes), placenta and umbilical cord blood cells, sampled immediately after birth in 296 Danish mother-child pairs from a birth cohort. Exposure data was obtained using the high-resolution and spatial-temporal air pollution modeling system DEHM-UBM-AirGIS for PM, PM, SO, NH, black carbon (BC), organic carbon (OC), CO, O, NO, and NO at residential and occupational addresses of the participating women for the full duration of the pregnancy. The association between prenatal exposure to air pollutants and TL was investigated using distributed lag models. There were significant and positive associations between TL in umbilical cord blood cells and prenatal exposure to BC, OC, NO, NO, CO, and O during the second trimester. TL in umbilical cord blood was significantly and inversely associated with prenatal exposure to PM, BC, OC, SO, NH, CO and NO during the third trimester. There were similar inverse associations between TL from umbilical cord blood cells and air pollution exposure at the residential and occupational addresses. There were weaker or no associations between air pollution exposure and TL in placenta tissue and maternal blood cells. In conclusion, both the second and third trimesters of pregnancy are shown to be sensitive windows of exposure to air pollution affecting fetal TL.
端粒长度（TL）是生物衰老的生物标志物，可能受到产前暴露于空气污染的影响。本研究旨在评估 296 对丹麦母婴对从出生队列中立即采集的母亲血液细胞（白细胞）、胎盘和脐带血细胞中产前暴露于空气污染与 TL 之间的关联。使用高分辨率和时空空气污染建模系统 DEHM-UBM-AirGIS 获得暴露数据，用于 PM、PM、SO、NH、黑碳 (BC)、有机碳 (OC)、CO、O、NO 和 NO 在参与妇女的居住和职业地址，以进行整个妊娠期间。使用分布式滞后模型研究了产前暴露于空气污染物与 TL 之间的关联。脐带血细胞中的 TL 与妊娠中期 BC、OC、NO、NO、CO 和 O 的产前暴露呈显著正相关。脐带血中的 TL 与妊娠晚期 PM、BC、OC、SO、NH、CO 和 NO 的产前暴露呈显著负相关。脐带血细胞中 TL 与住宅和职业地址的空气污染暴露之间存在类似的负相关。胎盘组织和母血细胞中的空气污染暴露与 TL 之间的关联较弱或不存在。总之，妊娠的第二和第三个三个月都被证明是易受空气污染影响胎儿 TL 的暴露敏感窗口。
